光动力疗法
细胞毒性
活性氧
抗菌活性
化学
癌细胞
体内
大肠杆菌
银纳米粒子
纳米技术
组合化学
癌症
纳米颗粒
癌症研究
体外
生物化学
材料科学
细菌
生物
生物技术
有机化学
基因
遗传学
作者
Tabbisa Namulinda,Zhi-Bing Song,Yi‐Jia Yan,Min Zhang,Г. А. Меерович,Davor Margetić,Zhilong Chen
出处
期刊:Nanomedicine
日期:2024-07-16
卷期号:19 (18-20): 1643-1658
被引量:1
标识
DOI:10.1080/17435889.2024.2370226
摘要
Aim: A study of the enhancement of photodynamic activities of pyropheophorbide-a using PG-Ag-PPa nanoconjugates. Materials & methods: The nanoconjugates were formulated from silver nanoparticles and PPa via amide linkage, then characterized, and their photodynamic activities were examined. Results: The nanoconjugates displayed a higher rate of reactive oxygen species generation, commendable cellular uptake by Eca-109 cancer cells, higher photocytotoxicity toward the cancer cells and better bio-safety. They revealed strong antibacterial activity against Escherichia coli following internal reactive oxygen species generation and membrane disintegration. The in vivo anticancer studies confirmed higher cytotoxicity of the nanoconjugates toward cancer cells and better safety than PPa. Conclusion: Therefore, PG-Ag-PPa nanoconjugates could be considered potential nano photosensitizers for photodynamic therapy of tumors and bacterial infection with good bio-safety.
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