乙醚
化学
烯丙基重排
过渡金属
酒
合成法
有机化学
取代反应
区域选择性
苯酚
替代(逻辑)
组合化学
催化作用
计算机科学
程序设计语言
作者
Chao Xu,Yingkun Luo,Shengtong Niu,Fan Gong,Shouang Lan,Benlong Luo,Jinggong Liu,Shuang Yang,Xinqiang Fang
标识
DOI:10.1016/j.gresc.2023.10.003
摘要
Ethers are among the most important chemicals in organic synthesis, the pharmaceutical industry, agrochemical production, and material science. C-O bond formation via substitution is one of the most widely used strategies for ether formation. However, known methods usually employ transition-metal and bases to facilitate the process. In this work, we describe the base- and transition-metal-free ether formation via alcohol and phenol-participated substitution. The protocol allows access to a large number of ethers with enyne functional moieties, and features mild reaction conditions, high efficiency, and good regio- and stereoselectivities. The reaction could be readily scaled up, and the products could be used in a range of further transformations.
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