转录组
腺癌
生物
免疫系统
病理
肺
病态的
计算生物学
医学
内科学
免疫学
遗传学
癌症
基因表达
基因
作者
Jiatao Zhang,Juan Zhang,Song-Rong Wang,Yan Li,Jing Qin,Ke Yin,Xiang‐Peng Chu,Meng-Min Wang,Hui-Zhao Hong,Zhiyi Lv,Song Dong,Ben‐Yuan Jiang,Xu‐Chao Zhang,Fei Liu,Qing Zhou,Yi‐Long Wu,Wen‐Zhao Zhong
出处
期刊:iScience
[Elsevier]
日期:2023-10-01
卷期号:26 (10): 107699-107699
被引量:3
标识
DOI:10.1016/j.isci.2023.107699
摘要
Pulmonary nodules with part-solid imaging features manifest during the progression from preinvasive to invasive lung adenocarcinoma. To define the spatial composition and evolutionary trajectories of early-stage lung adenocarcinoma, we combined spatial transcriptomics (ST) and pathological annotations from 20 part-solid nodules (PSNs), four of which were matched with single-cell RNA sequencing. Two malignant cell populations (MC1 and MC2) were identified, and a linear evolutionary relationship was observed. Compared to MC2, the pre-existing malignant MC1 exhibited a lower metastatic signature, corresponding to the preinvasive component (lepidic) on pathology and the ground glass component on PSN imaging. Higher immune infiltration was observed among MC1 regions in ST profiles, and further analysis revealed that macrophages may be involved in this process through the CD74 axis. This work provides deeper insights into the evolutionary process and spatial immune cell composition behind PSNs and highlights the mechanisms of immune escape behind this adenocarcinoma trajectory.
科研通智能强力驱动
Strongly Powered by AbleSci AI