纳米凝胶
两性离子
耗散颗粒动力学模拟
材料科学
高分子化学
化学工程
甲基丙烯酸酯
离子强度
聚合物
粒子(生态学)
共聚物
化学
纳米技术
复合材料
药物输送
有机化学
水溶液
工程类
地质学
海洋学
分子
作者
Zhaohong Miao,Lanlan Qin,Zhaoxi Zhou,Meng Zhang,Heqing Fu,Li‐Zhi Zhang,Jian Zhou
出处
期刊:Langmuir
[American Chemical Society]
日期:2023-09-15
卷期号:39 (38): 13678-13687
被引量:1
标识
DOI:10.1021/acs.langmuir.3c01875
摘要
The self-assembly and stimuli-responsive properties of nanogel poly(n-isopropylacrylamide) (p(NIPAm)) and zwitterion-modified nanogel poly(n-isopropylacrylamide-co-sulfobetainemethacrylate) (p(NIPAm-co-SBMA)) were explored by dissipative particle dynamics simulations. Simulation results reveal that for both types of nanogel, it is beneficial to form spherical nanogels at polymer concentrations of 5-10%. When the chain length (L) elongates from 10 to 40, the sizes of the nanogels enlarge. As for the p(NIPAm) nanogel, it shows thermoresponsiveness; when it switches to the hydrophilic state, the nanogel swells, and vice versa. The zwitterion-modified nanogel p(NIPAm-co-SBMA) possesses thermoresponsiveness and ionic strength responsiveness concurrently. At 293 K, both hydrophilic p(NIPAm) and superhydrophilic polysulfobetaine methacrylate (pSBMA) could appear on the outer surface of the nanogel; however, at 318 K, superhydrophilic pSBMA is on the outer surface to cover the hydrophobic p(NIPAm) core. As the temperature rises, the nanogel shrinks and remains antifouling all through. The salt-responsive property can be reflected by the nanogel size; the volumes of the nanogels in saline systems are larger than those in salt-free systems as the ionic condition inhibits the shrinkage of the zwitterionic pSBMA. This work exhibits the temperature-responsive and salt-responsive behavior of zwitterion-modified-pNIPAm nanogels at the molecular level and provides guidance in antifouling nanogel design.
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