神经退行性变
神经保护
氧化应激
神经科学
槲皮素
血脑屏障
药理学
药品
药物输送
程序性细胞死亡
脑老化
医学
脑组织
化学
生物
抗氧化剂
纳米技术
中枢神经系统
病理
生物化学
材料科学
内科学
疾病
细胞凋亡
认知
作者
Rajat Goyal,Garima Mittal,Sakshi Khurana,Neelam Malik,Vivek Kumar,Ankit Soni,Hitesh Chopra,Mohammad Amjad Kamal
出处
期刊:Current Pharmaceutical Biotechnology
[Bentham Science]
日期:2023-08-30
卷期号:25
标识
DOI:10.2174/1389201025666230830125410
摘要
The neurodegeneration process begins in conjunction with the aging of the neurons. It manifests in different parts of the brain as Aβ plaques, neurofibrillary tangles, Lewy bodies, Pick bodies, and other structures, which leads to progressive loss or death of neurons. Quercetin (QC) is a flavonoid compound found in fruits, tea, and other edible plants have antioxidant effects that have been studied from subcellular compartments to tissue levels in the brain. Also, quercetin has been reported to possess a neuroprotective role by decreasing oxidative stress-induced neuronal cell damage.The use of QC for neurodegenerative therapy, the existence of the blood-brain barrier (BBB) remains a significant barrier to improving the clinical effectiveness of the drug, so finding an innovative solution to develop simultaneous BBB-crossing ability of drugs for treating neurodegenerative disorders and improving neurological outcomes is crucial. The nanoparticle formulation of QC is considered beneficial and useful for its delivery through this route for the treatment of neurodegenerative diseases seems necessary. Increased QC accumulation in the brain tissue and more significant improvements in tissue and cellular levels are among the benefits of QC-involved nanostructures.
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