Advances in Peptide Synthesis

Peptide drug development has made significant progress over the last century. The discovery of solid-phase peptide synthesis has enabled chemists to synthesize various peptides with divergent sequence patterns. However, due to the increased demand for various peptide sequences in the modern pharmaceutical industry, there is always room for new methods to modify the existing methods to improve yield, purity, and synthesis time. The current century has witnessed a lot of progress in the field of peptide synthesis, including developments in new synthetic strategies, suitable selection of protecting groups, and introduction of efficient coupling reagents, as well as the development of automated peptide synthesizers. This chapter will give a summary of the recent reports on the most significant breakthroughs in peptide chemical synthesis in current years.