HMG co-reductase expression and response to intravesical Bacillus Calmette-Guérin in patients with high grade non-muscle invasive urinary bladder cancer receiving statins

医学 膀胱癌 HMG-CoA还原酶 生物标志物 他汀类 泌尿系统 内科学 泌尿科 卡介苗 队列 羟甲基戊二酰辅酶A还原酶抑制剂 癌症 肿瘤科 还原酶 病理 化学 接种疫苗 生物化学
作者
Jamie Krishnan,Andrew Symington,Neil M. Kernohan,Susan E. Bray,A J Robertson,Ghulam Nabi
出处
期刊:Scottish Medical Journal [SAGE Publishing]
卷期号:69 (1): 3-9
标识
DOI:10.1177/00369330231213935
摘要

Background Cardiovascular disease affects over 7 million people in the UK and statins are often prescribed to mitigate cardiovascular risks. The effect of statins on a number of cancers is debated and their effect on Bacillus Calmette-Guérin (BCG) responsiveness in non-muscle invasive urinary bladder cancer (NMIBC) is not fully understood. Aims This study aims to explore the difference in HMG Co-A reductase (HMGCR) expression in NMIBC on immunochemistry in BCG responders and non-responders while on statins. Method Three hundred and thirty-two cases of intravesical BCG treatment for high-risk NMIBC between November 2003 and December 2017 were identified. Patients taking statins for at least 12 months before the diagnosis of NIMBC and with a follow-up of at least 5 years were included. They were divided into BCG responders and non-responders. Tumour tissue from these patients was immunohistochemically stained and quantitative image analysis carried out to assess and compare HMGCR expression in the groups. Results & Conclusion This study showed a differential expression of HMGCR in responders vs. non-responders to BCG for high-risk NMIBC on statins. This data should form the basis of a further research and multi-centre study in a larger cohort, using HMGCR as a biomarker of response in patients on statins.
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