The role of radiation therapy in the management of primary retroperitoneal sarcoma: A systematic review and clinical practice guidelines from the Australia and New Zealand Sarcoma Association

医学 随机对照试验 围手术期 脂肪肉瘤 肉瘤 回顾性队列研究 软组织肉瘤 放射治疗 外科 内科学 肿瘤科 放射科 病理
作者
Anna Lawless,Deborah Zhou,Joshua McDonough,Helen Lo,Jasmine Mar,Smaro Lazarakis,Iain Ward,Joanna Connor,Stephen R. Thompson,David J. Coker,Andrew T. Johnston,David Gyorki,Angela Hong
出处
期刊:Cancer Treatment Reviews [Elsevier BV]
卷期号:120: 102620-102620 被引量:2
标识
DOI:10.1016/j.ctrv.2023.102620
摘要

While surgery is the mainstay of treatment for localised retroperitoneal sarcoma, the use of radiotherapy (RT) remains controversial. This systematic review aimed to evaluate the role of RT for retroperitoneal sarcoma.A systematic review using the population, intervention, comparison, and outcome model from 1990 to 2022 identified 66 studies (a mixture of preoperative and postoperative RT); one randomised controlled trial (RCT) with two publications, 18 registry studies, and 46 retrospective studies.In the RCT of preoperative RT, there was no difference in local/abdominal recurrence. The pooled analysis of this RCT and a retrospective study showed a significant abdominal recurrence free survival benefit with preoperative RT in low grade liposarcoma. The RCT and the majority of retrospective series found RT did not improve recurrence free survival (11 of 16 no difference in combined local and distant RFS, 11 of 13 no difference in distant metastasis free survival), disease specific survival (9 of 12 studies) or overall survival (33 of 49 studies). The majority of studies found no association between RT and perioperative morbidity.In summary, preoperative RT may improve local control for low grade (well-differentiated or grades 1-2 dedifferentiated) liposarcoma, but not other histological subtypes. There is no strong evidence that perioperative RT provides an overall survival benefit. Patients with low grade retroperitoneal liposarcoma can be considered for preoperative RT to improve abdominal recurrence free survival. The rationale and level of evidence in this scenario should be carefully discussed by the multidisciplinary team with patients. RT should not be routinely recommended for other histological subtypes.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
NMR发布了新的文献求助10
刚刚
Caicai发布了新的文献求助10
3秒前
3秒前
wts发布了新的文献求助10
4秒前
星辰大海应助zeng采纳,获得10
4秒前
5秒前
Stroeve发布了新的文献求助20
6秒前
6秒前
全能发文章完成签到,获得积分20
6秒前
Sure完成签到,获得积分10
7秒前
韩涵发布了新的文献求助10
9秒前
9秒前
9秒前
共享精神应助柴胡采纳,获得10
12秒前
影默发布了新的文献求助10
12秒前
water应助科研通管家采纳,获得10
13秒前
13秒前
yx_cheng应助科研通管家采纳,获得30
13秒前
顾矜应助科研通管家采纳,获得10
13秒前
鸡鱼蚝发布了新的文献求助10
13秒前
water应助吱吱采纳,获得10
13秒前
13秒前
SYLH应助科研通管家采纳,获得10
14秒前
SYLH应助科研通管家采纳,获得10
14秒前
张雷应助科研通管家采纳,获得20
14秒前
14秒前
14秒前
14秒前
14秒前
NexusExplorer应助科研通管家采纳,获得10
14秒前
SYLH应助科研通管家采纳,获得10
14秒前
yx_cheng应助科研通管家采纳,获得30
15秒前
爆米花应助科研通管家采纳,获得30
15秒前
SYLH应助科研通管家采纳,获得10
15秒前
15秒前
15秒前
科研通AI5应助科研通管家采纳,获得30
15秒前
张雷应助科研通管家采纳,获得20
15秒前
小蘑菇应助科研通管家采纳,获得10
15秒前
15秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Effective Learning and Mental Wellbeing 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975871
求助须知:如何正确求助?哪些是违规求助? 3520207
关于积分的说明 11201502
捐赠科研通 3256611
什么是DOI,文献DOI怎么找? 1798403
邀请新用户注册赠送积分活动 877552
科研通“疑难数据库(出版商)”最低求助积分说明 806430