Access to 2-thio/selenoquinolines via domino reaction of isocyanides with sulfur and selenium in water

A one-pot domino reaction of o -alkenylaryl isocyanides with elemental sulfur and selenium as well as FCH 2 I in water was developed for the efficient and divergent synthesis of 2-thio-/seleno-/fluoromethylthio-/fluoromethylseleno-quinoline derivatives.