Diagnostic accuracy of frozen section and patterns of nodal spread in high grade endometrial cancer: A secondary outcome of the SENTOR prospective cohort study

医学 子宫内膜癌 前哨淋巴结 前瞻性队列研究 阶段(地层学) 淋巴结切除术 活检 淋巴结 放射科 癌症 哨兵节点 内科学 乳腺癌 古生物学 生物
作者
Zibi Marchocki,Maria C. Cusimano,Danielle Vicus,Katherine Pulman,Marjan Rouzbahman,Jelena Mirković,Marilena Cesari,Manjula Maganti,Aysha Zia,Gabrielle Ene,Sarah E. Ferguson
出处
期刊:Gynecologic Oncology [Elsevier BV]
卷期号:173: 41-48 被引量:3
标识
DOI:10.1016/j.ygyno.2023.04.004
摘要

Objectives The study aimed to define the accuracy of intraoperative frozen section (FS) for the detection of metastases in sentinel lymph node biopsy (SLNB) and describe the pattern of lymph node (LN) spread and relation to molecular classifiers in patients with high-grade endometrial cancer (EC). Methods We performed a secondary outcome of clinicopathologic data from the Sentinel Lymph Node Biopsy versus Lymphadenectomy for Intermediate- and High-Grade Endometrial Cancer Staging (SENTOR) prospective cohort study evaluating SLNB in patients with clinical stage I high-grade EC (ClinicalTrials.gov ID: NCT01886066). The primary outcome was the sensitivity of FS of the sentinel lymph node (SLN) specimen, compared to a standardized ultrastaging protocol. Secondary outcomes included the pattern and characteristics of LN spread. Results There were 126 patients with high-grade EC with a median age of 66 years (range:44–86) and a median Body Mass Index (BMI) of 26.9 kg/m2 (range:17.6–49.3). FS was performed on surgical specimens from 212 hemipelves; SLNs were identified in 202 specimens (95.7%) and fatty tissue alone was identified in 10 specimens (4.7%). Of the 202 hemipelves in which SLNs were identified, 24 were positive for metastatic disease on final pathology. Initial FS correctly identified only 12, yielding a sensitivity of 50% (12/24, 95% CI 29.6–70.4) and a negative predictive value of 94% (178/190, 95% CI 89–96.5). A total of 24 patients (19%) had LN metastases: 16 (13%) had isolated pelvic metastases, 7 (6%) had both pelvic and para-aortic metastases and 1 (0.8%) had an isolated para-aortic metastasis. Conclusions Intraoperative FS of SLNs in high-grade EC patients has poor sensitivity. Since isolated para-aortic metastases are rare, para-aortic lymphadenectomy may be omitted in patients in which SLNs were successfully mapped to the pelvis.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
lilyz求学完成签到,获得积分10
1秒前
从若应助简单采纳,获得10
1秒前
3秒前
马前人发布了新的文献求助30
4秒前
5秒前
鄂海菡完成签到,获得积分10
6秒前
6秒前
ding应助拾新采纳,获得10
6秒前
太陽发布了新的文献求助10
8秒前
鲤鱼完成签到,获得积分10
8秒前
蜂蜜罐zi发布了新的文献求助20
11秒前
大模型应助chun采纳,获得10
11秒前
11秒前
田様应助czc采纳,获得10
12秒前
英俊绝义发布了新的文献求助10
12秒前
斯文败类应助三石呦423采纳,获得10
12秒前
赘婿应助鲤鱼采纳,获得10
13秒前
13秒前
13秒前
13秒前
量子星尘发布了新的文献求助10
14秒前
小二郎应助Vincent采纳,获得10
14秒前
秉烛夜游完成签到,获得积分10
14秒前
吃的饱饱呀完成签到 ,获得积分10
15秒前
15秒前
lisiying完成签到,获得积分20
17秒前
17秒前
tjusasa发布了新的文献求助10
17秒前
英俊绝义完成签到,获得积分10
17秒前
要减肥的乌龟完成签到,获得积分10
18秒前
啊啊发布了新的文献求助10
18秒前
Zer完成签到,获得积分10
19秒前
lisiying发布了新的文献求助10
20秒前
20秒前
MchemG举报乐正熠彤求助涉嫌违规
21秒前
21秒前
路十三发布了新的文献求助10
22秒前
朵拉A梦完成签到,获得积分10
22秒前
23秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975814
求助须知:如何正确求助?哪些是违规求助? 3520123
关于积分的说明 11201020
捐赠科研通 3256502
什么是DOI,文献DOI怎么找? 1798347
邀请新用户注册赠送积分活动 877523
科研通“疑难数据库(出版商)”最低求助积分说明 806417