肺孢子虫病
菌丝体
菌丝
抗真菌
化学
真菌生长
立体化学
植物
微生物学
生物
作者
Fu‐Tian Gao,Jun Jin,Jun-you Jian,Liang Chen,Wei Gu,Chun‐Mao Yuan,Xiao‐Jiang Hao,Lie‐Jun Huang
标识
DOI:10.1002/cbdv.202300442
摘要
Abstract To discover novel and effective antifungal candidates, a series of new curcumol derivatives were designed, synthesized, and evaluated their antifungal activity against five phytopathogenic fungi by the mycelium growth rate method. Derivatives c4 , c22 and c23 exhibited excellent antifungal activity against Phomopsis sp. with EC 50 values of 3.06, 3.07, and 3.16 μM, respectively. Specifically, compound c4 exhibited the strongest antifungal activity against Phomopsis sp., which was 44 times that of pyrimethanil (EC 50 =134.37 μM). The results of scanning electron microscopy (SEM) and transmission electron microscopy (TEM) indicated that compound c4 could cause cell senescence and death of Phomopsis sp. by changing the normal hyphal morphology and disrupting the normal metabolism of hyphal cells. Moreover, compound c4 showed excellent curative effect against Phomopsis sp. on kiwifruit. These findings confirmed that compound c4 has great potential as a potent antifungal agent.
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