Gut microbiota in pregnancy, please don’t change me now

Pregnancy predisposes women to develop severe sepsis. However, the mechanisms regulating this remain unclear. In this issue of Immunity, Chen et al. describe the critical role of gut dysbiosis during pregnancy in driving excessive macrophage pyroptosis, increasing susceptibility to sepsis. Pregnancy predisposes women to develop severe sepsis. However, the mechanisms regulating this remain unclear. In this issue of Immunity, Chen et al. describe the critical role of gut dysbiosis during pregnancy in driving excessive macrophage pyroptosis, increasing susceptibility to sepsis. Pregnancy-induced changes to the gut microbiota drive macrophage pyroptosis and exacerbate septic inflammationChen et al.ImmunityFebruary 14, 2023In BriefPregnancy worsens the outcomes of sepsis, but the mechanism remains poorly understood. Chen et al. demonstrate that the gut microbiota compositions are altered during pregnancy. The dysbiotic intestinal microbiota accelerates immune dysfunction in pregnant septic individuals, shedding light on potential therapeutic approaches for sepsis. Full-Text PDF