Recovery of dialysis-dependent acute kidney injury after cessation of oxaliplatin

Oxaliplatin, a platinum-based compound, is the standard cancer therapy for treatment of metastatic colorectal carcinoma and other gastrointestinal malignancies. Oxaliplatin-induced nephrotoxicities include acute kidney injury due to acute tubular injury secondary to diarrhea and pre-renal azotemia, though intravascular hemolysis and thrombotic microangiopathy have been also reported. Patients with oxaliplatin-induced kidney failure partially recover kidney function after cessation of oxaliplatin therapy. We report a unique case of a 61-year-old female, with metastatic colon cancer to her lungs, liver, spleen, and peritoneum, who presented with acute anemia, sepsis, and kidney failure post-oxaliplatin treatment. Oxaliplatin cessation resulted in complete kidney recovery after 3 months of kidney replacement therapy.