纳米反应器
酶
化学
催化作用
固定化酶
细胞器
表面改性
人工酶
级联
纳米技术
组合化学
生物物理学
生物化学
材料科学
生物
色谱法
物理化学
作者
Xingyue He,Qing Wu,Chen Hou,Min Hu,Qigang Wang,Xia Wang
标识
DOI:10.1002/anie.202218766
摘要
Some cellular enzymatic pathways are located within a single organelle, while most others involve enzymes that are located within multiple compartmentalized cellular organelles to realize the efficient multi-step enzymatic process. Herein, bioinspired by enzyme-mediated biosynthesis and biochemical defense, a compartmented nanoreactor (Burr-NCs@GlSOD ) was constructed through a self-confined catalysis strategy with burr defect-engineered molybdenum disulfide/Prussian blue analogues (MoS2 /PBA) and an interfacial diffusion-controlled hydrogel network. The specific catalytic mechanism of the laccase-like superactivity induced hydrogelation and cascade enzyme catalytic therapy were explored. The confined hydrogelation strategy introduces a versatile means for nanointerface functionalization and provides insight into biological construction of simulated enzymes with comparable activity and also the specificity to natural enzymes.
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