Patients With Autoimmune Hepatitis and Nonalcoholic Fatty Liver Disease

医学 自身免疫性肝炎 非酒精性脂肪肝 内科学 胃肠病学 肝移植 肝硬化 肝活检 肝病 重叠综合征 脂肪肝 肝炎 疾病 移植 活检
作者
Jessica Strzepka,Benjamin Schwartz,Ethan M. Ritz,Costica Aloman,Nancy Reau
出处
期刊:Journal of Clinical Gastroenterology [Ovid Technologies (Wolters Kluwer)]
卷期号:58 (1): 91-97 被引量:3
标识
DOI:10.1097/mcg.0000000000001817
摘要

Goal: The objective of this study was to characterize an autoimmune hepatitis (AIH)/nonalcoholic fatty liver disease (NAFLD) overlap cohort, determine if they received standard of care treatment, and delineate their outcomes in comparison with patients with AIH or NAFLD alone. Background: AIH is a relatively rare and heterogeneously presenting liver disease of unknown etiology. NAFLD is a leading cause of liver disease worldwide. AIH treatment includes steroids, which have adverse metabolic effects that can worsen NAFLD. No treatment guidelines are available to mitigate this side on AIH/NAFLD overlap patients. Few studies to date have examined these patients’ characteristics, management practices, and outcomes. Materials and Methods: A single-center, retrospective chart review study examining biopsy-proven AIH/NAFLD, AIH, and NAFLD patients. Characteristics, treatment, and 1- and 3-year outcomes (all-cause mortality, need for liver transplantation, or decompensated cirrhosis) were evaluated. Results: A total of 72 patients (36.1% AIH/NAFLD, 34.7% AIH, and 29.2% NAFLD) were included. AIH/NAFLD patients were found to be more often Hispanic/Latino, female, and with lower liver aminotransaminases, immunoglobulin G, and anti–smooth muscle antibody positivity. AIH/NAFLD patients were less likely to receive standard of care treatment. No significant differences in outcomes were seen between AIH/NAFLD and either AIH or NAFLD. Conclusions: Our study demonstrated that AIH/NAFLD patients have unique characteristics and are less likely to receive standard of care treatment compared with patients with AIH alone. Despite this, no difference in outcomes (all-cause mortality, need for liver transplantation, or decompensated cirrhosis) was seen. Given NAFLD’s rising prevalence, AIH/NAFLD cases will likely increase, and may benefit from alternative treatment guidelines to prevent worsening of NAFLD.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
wwww发布了新的文献求助10
刚刚
刚刚
春鸮鸟完成签到 ,获得积分10
刚刚
寻道图强应助跳跃尔琴采纳,获得30
刚刚
山隐隐水迢迢应助SL采纳,获得20
刚刚
1秒前
风吹发布了新的文献求助10
1秒前
huangyj完成签到,获得积分20
1秒前
wpc2o1o完成签到,获得积分10
2秒前
mm发布了新的文献求助20
2秒前
脑洞疼应助pan采纳,获得10
2秒前
黄花发布了新的文献求助10
3秒前
3秒前
3秒前
3秒前
4秒前
123完成签到,获得积分10
4秒前
花的微笑完成签到,获得积分10
4秒前
nt1119完成签到 ,获得积分10
4秒前
TMOMOR发布了新的文献求助10
5秒前
东方雨季发布了新的文献求助10
5秒前
passenger.发布了新的文献求助10
5秒前
懒懒洋洋洋完成签到 ,获得积分10
6秒前
Soleil完成签到 ,获得积分10
7秒前
seattle发布了新的文献求助10
7秒前
smrsmr完成签到,获得积分10
7秒前
乐乐应助田田田chong采纳,获得10
8秒前
无敌鱼发布了新的文献求助10
8秒前
Legend_应助秀丽的千山采纳,获得30
8秒前
拽根大恐龙完成签到,获得积分10
9秒前
赵书杰完成签到,获得积分10
9秒前
脑洞疼应助Spark采纳,获得10
9秒前
10秒前
东方雨季完成签到,获得积分10
11秒前
星光完成签到,获得积分10
11秒前
四月的海棠完成签到 ,获得积分10
11秒前
Jiny完成签到,获得积分10
12秒前
12秒前
依依给依依的求助进行了留言
12秒前
12秒前
高分求助中
The ACS Guide to Scholarly Communication 2500
Sustainability in Tides Chemistry 2000
Studien zur Ideengeschichte der Gesetzgebung 1000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Threaded Harmony: A Sustainable Approach to Fashion 810
Pharmacogenomics: Applications to Patient Care, Third Edition 800
Gerard de Lairesse : an artist between stage and studio 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3081744
求助须知:如何正确求助?哪些是违规求助? 2734831
关于积分的说明 7534536
捐赠科研通 2384276
什么是DOI,文献DOI怎么找? 1264252
科研通“疑难数据库(出版商)”最低求助积分说明 612606
版权声明 597600