Correlation of Serum Chemokine Ligand 14 with Barcelona Clinic Liver Cancer Stage, Lymphocyte Profile, and Response to Transarterial Chemoembolization in Patients with Hepatocellular Carcinoma

医学 肝细胞癌 内科学 阶段(地层学) 胃肠病学 危险系数 比例危险模型 生物标志物 肝癌 实体瘤疗效评价标准 肿瘤科 前瞻性队列研究 癌症 临床试验 置信区间 临床研究阶段 生物 古生物学 化学 生物化学
作者
Yuan Guo,Hong-Tao Hu,Shi Jun Xu,Wei Li Xia,Yan Li,Jun Lü,Xiao Zhao,Yan Zhao,Fang Ting Li,Hai Liang Li
出处
期刊:Journal of Vascular and Interventional Radiology [Elsevier BV]
卷期号:34 (6): 991-998 被引量:4
标识
DOI:10.1016/j.jvir.2023.01.032
摘要

Purpose To investigate the clinical relevance of serum chemokine ligand 14 (sCCL14) in patients with hepatocellular carcinoma (HCC) and the effect of transarterial chemoembolization (TACE) on the expression level of sCCL14 and the immune microenvironment. Materials and Methods In this prospective single-center observational study, 52 patients with HCC were recruited from January 2019 to December 2021, their clinical data and blood samples were collected, and the relationship between sCCL14 and progression-free survival (PFS) and TACE treatment response was analyzed. Results Among the 52 patients with HCC (Barcelona Clinic Liver Cancer [BCLC] Stage A, 25.0%; BCLC Stage B, 44.2%; and BCLC Stage C, 30.8%), patients with BCLC Stage C HCC had significantly lower sCCL14 levels than those of patients with BCLC Stages A and B HCC (P = .001). sCCL14 levels were significantly higher in the first week after treatment than before TACE treatment (P = .024). Baseline sCCL14 levels in patients who showed complete response after TACE treatment were significantly higher than those in other groups, and lower baseline sCCL14 values were associated with shorter PFS times. Multivariate Cox regression analysis showed that sCCL14 level (hazard ratio, 1.855; 95% CI, 1.039–3.311; P = .037) was an independent prognostic factor of PFS. sCCL14 levels negatively correlated with the proportion of B lymphocytes and regulatory T cells in circulating blood and positively correlated with the absolute T-lymphocyte count. Conclusions sCCL14 may be a predictive biomarker of TACE effectiveness. Further studies are needed to validate and outline the role of combination immunotherapy.
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