已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Contribution of intraoperative electroencephalogram suppression to frailty-associated postoperative delirium: mediation analysis of a prospective surgical cohort

医学 谵妄 前瞻性队列研究 麻醉 脑电图 队列研究 队列 内科学 重症监护医学 精神科
作者
Panpan Fang,Zi-xiang Shang,Jian Xu,Jun Hu,Si-chen Zhang,Yin‐Guang Fan,Yao Lu,Xuesheng Liu,Mervyn Maze
出处
期刊:BJA: British Journal of Anaesthesia [Elsevier BV]
卷期号:130 (2): e263-e271 被引量:8
标识
DOI:10.1016/j.bja.2022.11.002
摘要

Frailty is a risk factor for postoperative delirium (POD), and has led to preoperative interventions that have reduced, but not eliminated, the risk. We hypothesised that EEG suppression, another risk factor for POD, mediates some of the frailty risk for POD.A prospective cohort study enrolled patients aged 65 yr or older, scheduled for noncardiac surgery under total intravenous anaesthesia. Frailty was assessed using the FRAIL scale. Cumulative duration of EEG suppression, defined as an amplitude between -5 and 5 μV for >0.5 s during anaesthesia, was measured. POD was diagnosed by either confusion assessment method (CAM), CAM-ICU, or medical records. The severity of POD was assessed using the Delirium Rating Scale - Revised-98 (DRS). Mediation analysis was used to estimate the relationships between frailty, EEG suppression, and severity of POD.Among 252 enrolled patients, 51 were robust, 129 were prefrail, and 72 were frail. Patients classified as frail had higher duration of EEG suppression than either the robust (19 vs 0.57 s, P<0.001) or prefrail groups (19 vs 3.22 s, P<0.001). Peak delirium score was higher in the frail group than either the robust (17 vs 15, P<0.001) or prefrail groups (17 vs 16, P=0.007). EEG suppression time mediated 24.2% of the frailty-DRS scores association.EEG suppression time mediated a statistically significant portion of the frailty-POD association in older noncardiac surgery patients. Trials directed at reducing EEG suppression time could result in intraoperative interventions to reduce POD in frail patients.ChiCTR2000041092 (Chinese Clinical Trial Registry).
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
为医消得人憔悴完成签到 ,获得积分10
1秒前
zjgjnu发布了新的文献求助10
2秒前
2秒前
3秒前
Peter发布了新的文献求助10
4秒前
瘦瘦语蕊完成签到,获得积分10
7秒前
8秒前
8秒前
Steven发布了新的文献求助10
8秒前
9秒前
哈哈完成签到,获得积分10
10秒前
共享精神应助科研通管家采纳,获得10
11秒前
11秒前
11秒前
Rondab应助科研通管家采纳,获得10
11秒前
香蕉觅云应助科研通管家采纳,获得10
11秒前
Rondab应助科研通管家采纳,获得10
11秒前
11秒前
田様应助科研通管家采纳,获得10
11秒前
dapis完成签到,获得积分10
11秒前
Rondab应助科研通管家采纳,获得10
11秒前
orixero应助科研通管家采纳,获得10
11秒前
汉堡包应助科研通管家采纳,获得10
11秒前
11秒前
SciGPT应助科研通管家采纳,获得10
11秒前
11秒前
11秒前
研友_LNM558完成签到,获得积分20
15秒前
一直向前发布了新的文献求助10
15秒前
16秒前
momo发布了新的文献求助10
18秒前
哈哈发布了新的文献求助10
20秒前
fanyueyue应助dart1023采纳,获得10
20秒前
1111完成签到 ,获得积分10
25秒前
旭007完成签到,获得积分20
26秒前
烟花应助Beyond采纳,获得30
27秒前
负责怀莲发布了新的文献求助10
28秒前
29秒前
旭007发布了新的文献求助10
31秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989857
求助须知:如何正确求助?哪些是违规求助? 3531994
关于积分的说明 11255679
捐赠科研通 3270758
什么是DOI,文献DOI怎么找? 1805053
邀请新用户注册赠送积分活动 882195
科研通“疑难数据库(出版商)”最低求助积分说明 809208