Polyethersulfone is most extensively utilized material in waste treatment application via membranes technology since it offers high thermal, chemical, and mechanical properties. The world now has problems with drinking water and the present situation seems to be very complex to meet clean water requirements. The treatment of water supplies by clean-up techniques is urgently considered by increased daily demand, which leads to dangerous conditions unless this problem is controlled. Most important contributors to ecological pollution with metal ions are mining, metal shining, power generation houses, galvanization, tannery industries, metallurgical, and electroplating. There are many techniques to remove the metal ions such as adsorption, microbial fuel cells, oxidation/reductions, ion exchange etc. Among all the technologies nanofiltration membranes attract more attention to remove the toxic metal ions from water even at lower concentration. It is very simple, feasible and economically affordable technology. Several types of nanofiltration techniques are used before but most attractive is polyethersulfone (PES) nanofiltration membrane. It minimizes several issues which are present in the nanofiltration process. In this chapter we briefly discussed the modification strategies and removal efficiency of metal ions via polyethersulfone (PES) nanofiltration membrane.