THERAPEUTIC MANAGEMENT OF ADULTS WITH EPILEPSY. With the development of numerous antiseizure medications, therapeutic options for the management of patients suffering from epilepsy have greatly diversified. This diversification of the therapeutic arsenal means that treatment can now be better adapted to each individual patient. The choice of molecule for new-onset epilepsy in adults thus takes into account both the expected efficacy of the molecule in the epileptic syndrome from which the patient suffers, and its suitability for the patient's specific characteristics, whether in terms of gender, age or co-morbidities. This approach is essential for all patients, with particular attention to young women of childbearing age. In situations of drug resistance, it is essential to remain alert to the risk of treatment side-effects, without ignoring non-pharmacological options. This is particularly important in the case of focal epilepsies, where the pre-surgical evaluation must be discussed as a matter of principle.