Blood Glucose Monitoring In article number 2208820, Qiao Jiang, Baoquan Ding, Yan Wu, Ran Liu, and co-workers describe a fluorescence-amplified origami microneedle (FAOM) device for quantitatively monitoring blood glucose. Through collaboratively integrating the advantages of fluorescence imaging, DNA origami, and the microneedle patch, the FAOM device can monitor blood glucose in real-time in a trivially painful, highly sensitive and accurate manner, thus improving test tolerance and patient compliance.