Thiolutin, a selective NLRP3 inflammasome inhibitor, attenuates cyclophosphamide–induced impairment of sperm and fertility in mice

Objective The activation of the NLRP3 inflammasome has been implicated in male infertility. Our study aimed to investigate the therapeutic role of Thiolutin (THL), an inhibitor of the NLRP3 inflammasome, on oligoasthenospermia (OA) and to elucidate its mechanisms.