The effects of Micro/Nano-plastics exposure on plants and their toxic mechanisms: A review from multi-omics perspectives

In recent years, plastic pollution has become a global environmental problem, posing a potential threat to agricultural ecosystems and human health, and may further exacerbate global food security problems. Studies have revealed that exposure to micro/nano-plastics (MPs/NPs) might cause various aspects of physiological toxicities, including plant biomass reduction, intracellular oxidative stress burst, photosynthesis inhibition, water and nutrient absorption reduction, cellular and genotoxicity, seed germination retardation, and that the effects were closely related to MP/NP properties (type, particle size, functional groups), exposure concentration, exposure duration and plant characteristics (species, tissue, growth stage). Based on a brief review of the physiological toxicity of MPs/NPs to plant growth, this paper comprehensively reviews the potential molecular mechanism of MPs/NPs on plant growth from perspectives of multi-omics, including transcriptome, metabolome, proteome and microbiome, thus to reveal the role of MPs/NPs in plant transcriptional regulation, metabolic pathway reprogramming, protein translational and post-translational modification, as well as rhizosphere microbial remodeling at multiple levels. Meanwhile, this paper also provides prospects for future research, and clarifies the future research directions and the technologies adopted. Micro/nano-plastics exert toxicities on plant growth, including reducing the plant biomass, causing oxidative stress, inhibiting photosynthesis, altering water and nutrient uptake, bringing about cellular and genotoxic effects, and repressing seed germination, and can also cause combined toxicities with other pollutants (such as heavy metals) through adsorption. Elucidating the molecular mechanisms underlying Micro/nano-plastics stress on plants from multi-omics perspectives is beneficial for us to gain a deeper understanding of plant responses to microplastic stress.