Characterization of genomic regions escaping epigenetic reprogramming in sheep

重编程 表观遗传学 基因组印记 生物 DNA甲基化 遗传学 基因 基因表达
作者
Camila Urbano Braz,Matilde Maria Passamonti,Hasan Khatib
出处
期刊:Current Zoology [Oxford University Press]
卷期号:10 (1)
标识
DOI:10.1093/eep/dvad010
摘要

The mammalian genome undergoes two global epigenetic reprogramming events during the establishment of primordial germ cells and in the pre-implantation embryo after fertilization. These events involve the erasure and re-establishment of DNA methylation marks. However, imprinted genes and transposable elements (TEs) maintain their DNA methylation signatures to ensure normal embryonic development and genome stability. Despite extensive research in mice and humans, there is limited knowledge regarding environmentally induced epigenetic marks that escape epigenetic reprogramming in other species. Therefore, the objective of this study was to examine the characteristics and locations of genomic regions that evade epigenetic reprogramming in sheep, as well as to explore the biological functions of the genes within these regions. In a previous study, we identified 107 transgenerationally inherited differentially methylated cytosines (DMCs) in the F1 and F2 generations in response to a paternal methionine-supplemented diet. These DMCs were found in TEs, non-repetitive regions, and imprinted and non-imprinted genes. Our findings suggest that genomic regions, rather than TEs and imprinted genes, have the propensity to escape reprogramming and serve as potential candidates for transgenerational epigenetic inheritance. Notably, 34 transgenerational methylated genes influenced by paternal nutrition escaped reprogramming, impacting growth, development, male fertility, cardiac disorders, and neurodevelopment. Intriguingly, among these genes, 21 have been associated with neural development and brain disorders, such as autism, schizophrenia, bipolar disease, and intellectual disability. This suggests a potential genetic overlap between brain and infertility disorders. Overall, our study supports the concept of transgenerational epigenetic inheritance of environmentally induced marks in mammals.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
与其会意发布了新的文献求助10
1秒前
1111发布了新的文献求助10
1秒前
2秒前
3秒前
Suraim完成签到,获得积分10
3秒前
哈哈哈完成签到,获得积分10
4秒前
Meng发布了新的文献求助100
5秒前
dydy发布了新的文献求助10
6秒前
打野完成签到,获得积分10
6秒前
6秒前
7秒前
Lynette8888完成签到 ,获得积分10
7秒前
南极冰完成签到 ,获得积分10
9秒前
10秒前
11秒前
11秒前
汐月发布了新的文献求助10
13秒前
三石发布了新的文献求助10
14秒前
劲秉应助甩看文献采纳,获得10
14秒前
15秒前
JxJ发布了新的文献求助10
15秒前
GaoYuan发布了新的文献求助20
16秒前
Sarah完成签到,获得积分10
16秒前
17秒前
17秒前
顾矜应助帅哥采纳,获得10
18秒前
18秒前
XLXY完成签到,获得积分20
20秒前
zzz发布了新的文献求助10
20秒前
天天快乐应助tabblk采纳,获得20
20秒前
Gifted发布了新的文献求助10
21秒前
帅气的盼芙完成签到,获得积分20
21秒前
22秒前
1111发布了新的文献求助10
24秒前
Ava应助岳麓山老农采纳,获得10
24秒前
小蘑菇应助岳麓山老农采纳,获得10
24秒前
Ava应助岳麓山老农采纳,获得10
24秒前
隐形曼青应助岳麓山老农采纳,获得10
24秒前
充电宝应助岳麓山老农采纳,获得10
24秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
安全防范技术与工程 500
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
2-Acetyl-1-pyrroline: an important aroma component of cooked rice 500
A real-time energy management strategy based on fuzzy control and ECMS for PHEVs 400
2024 Medicinal Chemistry Reviews 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3190944
求助须知:如何正确求助?哪些是违规求助? 2840198
关于积分的说明 8027276
捐赠科研通 2503491
什么是DOI,文献DOI怎么找? 1336900
科研通“疑难数据库(出版商)”最低求助积分说明 637973
邀请新用户注册赠送积分活动 606323