Characterization of genomic regions escaping epigenetic reprogramming in sheep

重编程 表观遗传学 基因组印记 生物 DNA甲基化 遗传学 基因 基因表达
作者
Camila Urbano Braz,Matilde Maria Passamonti,Hasan Khatib
出处
期刊:Current Zoology [Oxford University Press]
卷期号:10 (1)
标识
DOI:10.1093/eep/dvad010
摘要

The mammalian genome undergoes two global epigenetic reprogramming events during the establishment of primordial germ cells and in the pre-implantation embryo after fertilization. These events involve the erasure and re-establishment of DNA methylation marks. However, imprinted genes and transposable elements (TEs) maintain their DNA methylation signatures to ensure normal embryonic development and genome stability. Despite extensive research in mice and humans, there is limited knowledge regarding environmentally induced epigenetic marks that escape epigenetic reprogramming in other species. Therefore, the objective of this study was to examine the characteristics and locations of genomic regions that evade epigenetic reprogramming in sheep, as well as to explore the biological functions of the genes within these regions. In a previous study, we identified 107 transgenerationally inherited differentially methylated cytosines (DMCs) in the F1 and F2 generations in response to a paternal methionine-supplemented diet. These DMCs were found in TEs, non-repetitive regions, and imprinted and non-imprinted genes. Our findings suggest that genomic regions, rather than TEs and imprinted genes, have the propensity to escape reprogramming and serve as potential candidates for transgenerational epigenetic inheritance. Notably, 34 transgenerational methylated genes influenced by paternal nutrition escaped reprogramming, impacting growth, development, male fertility, cardiac disorders, and neurodevelopment. Intriguingly, among these genes, 21 have been associated with neural development and brain disorders, such as autism, schizophrenia, bipolar disease, and intellectual disability. This suggests a potential genetic overlap between brain and infertility disorders. Overall, our study supports the concept of transgenerational epigenetic inheritance of environmentally induced marks in mammals.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
spiritpope发布了新的文献求助10
3秒前
宝宝巴士驾驶员完成签到,获得积分10
6秒前
FireNow完成签到 ,获得积分10
6秒前
天天快乐应助咕噜咕噜采纳,获得10
6秒前
小事完成签到 ,获得积分10
7秒前
weijie完成签到,获得积分10
11秒前
科研临床两手抓完成签到 ,获得积分10
11秒前
Muccio完成签到 ,获得积分10
16秒前
tangchao完成签到,获得积分10
17秒前
xingxing完成签到 ,获得积分10
20秒前
EMMACao完成签到,获得积分10
20秒前
萧水白完成签到,获得积分10
20秒前
benny279完成签到,获得积分10
21秒前
Zero完成签到,获得积分10
24秒前
orixero应助司徒无剑采纳,获得10
26秒前
汕头凯奇完成签到,获得积分10
28秒前
高高菠萝完成签到 ,获得积分10
29秒前
Dawn完成签到,获得积分10
30秒前
咕噜咕噜完成签到,获得积分10
35秒前
纳米完成签到 ,获得积分10
37秒前
娜写年华完成签到 ,获得积分10
39秒前
40秒前
科研通AI2S应助科研通管家采纳,获得10
41秒前
汉堡包应助科研通管家采纳,获得10
41秒前
陈坤完成签到,获得积分10
41秒前
鱼儿忆流年完成签到 ,获得积分10
42秒前
43秒前
梧桐雨210完成签到 ,获得积分10
45秒前
笑林完成签到 ,获得积分10
51秒前
方好完成签到,获得积分10
51秒前
chiron完成签到,获得积分10
54秒前
58秒前
summer完成签到 ,获得积分0
59秒前
司徒无剑发布了新的文献求助10
1分钟前
洋洋爱吃枣完成签到 ,获得积分10
1分钟前
xiaofeng5838完成签到,获得积分10
1分钟前
帆帆帆完成签到 ,获得积分10
1分钟前
我唉科研完成签到,获得积分10
1分钟前
luckygirl完成签到 ,获得积分10
1分钟前
momo完成签到,获得积分10
1分钟前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
安全防范技术与工程 500
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
2024 Medicinal Chemistry Reviews 400
Актуализированная стратиграфическая схема триасовых отложений Прикаспийского региона. Объяснительная записка 360
Dictionary of socialism 350
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3192710
求助须知:如何正确求助?哪些是违规求助? 2841763
关于积分的说明 8034633
捐赠科研通 2505463
什么是DOI,文献DOI怎么找? 1338603
科研通“疑难数据库(出版商)”最低求助积分说明 638372
邀请新用户注册赠送积分活动 606929