Characterization of genomic regions escaping epigenetic reprogramming in sheep

重编程 表观遗传学 基因组印记 生物 DNA甲基化 遗传学 基因 基因表达
作者
Camila Urbano Braz,Matilde Maria Passamonti,Hasan Khatib
出处
期刊:Current Zoology [Oxford University Press]
卷期号:10 (1)
标识
DOI:10.1093/eep/dvad010
摘要

The mammalian genome undergoes two global epigenetic reprogramming events during the establishment of primordial germ cells and in the pre-implantation embryo after fertilization. These events involve the erasure and re-establishment of DNA methylation marks. However, imprinted genes and transposable elements (TEs) maintain their DNA methylation signatures to ensure normal embryonic development and genome stability. Despite extensive research in mice and humans, there is limited knowledge regarding environmentally induced epigenetic marks that escape epigenetic reprogramming in other species. Therefore, the objective of this study was to examine the characteristics and locations of genomic regions that evade epigenetic reprogramming in sheep, as well as to explore the biological functions of the genes within these regions. In a previous study, we identified 107 transgenerationally inherited differentially methylated cytosines (DMCs) in the F1 and F2 generations in response to a paternal methionine-supplemented diet. These DMCs were found in TEs, non-repetitive regions, and imprinted and non-imprinted genes. Our findings suggest that genomic regions, rather than TEs and imprinted genes, have the propensity to escape reprogramming and serve as potential candidates for transgenerational epigenetic inheritance. Notably, 34 transgenerational methylated genes influenced by paternal nutrition escaped reprogramming, impacting growth, development, male fertility, cardiac disorders, and neurodevelopment. Intriguingly, among these genes, 21 have been associated with neural development and brain disorders, such as autism, schizophrenia, bipolar disease, and intellectual disability. This suggests a potential genetic overlap between brain and infertility disorders. Overall, our study supports the concept of transgenerational epigenetic inheritance of environmentally induced marks in mammals.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
ajax完成签到,获得积分10
1秒前
Jiang发布了新的文献求助10
1秒前
加菲丰丰应助白华苍松采纳,获得20
3秒前
太阳花发布了新的文献求助10
3秒前
打打应助Edison采纳,获得10
4秒前
ajax发布了新的文献求助30
5秒前
5秒前
99411完成签到 ,获得积分10
9秒前
11秒前
shain发布了新的文献求助10
11秒前
12秒前
伶俐雅柏完成签到,获得积分20
15秒前
MLR发布了新的文献求助10
15秒前
Orange应助认真的荔枝采纳,获得10
17秒前
科研小白发布了新的文献求助10
18秒前
lm完成签到,获得积分20
19秒前
廖无极完成签到 ,获得积分10
20秒前
落寞雪冥发布了新的文献求助10
20秒前
22秒前
hityuliangru完成签到,获得积分10
22秒前
24秒前
科研通AI2S应助疯狂的迪子采纳,获得10
24秒前
卓若之完成签到 ,获得积分10
24秒前
迈克老狼发布了新的文献求助10
26秒前
Lee完成签到,获得积分10
26秒前
MLR完成签到,获得积分10
27秒前
言午完成签到,获得积分10
28秒前
sheh发布了新的文献求助10
29秒前
weiwei发布了新的文献求助10
29秒前
乔树伟完成签到,获得积分10
33秒前
陈十一完成签到,获得积分10
33秒前
34秒前
34秒前
34秒前
34秒前
烟花应助科研通管家采纳,获得10
34秒前
赘婿应助科研通管家采纳,获得10
34秒前
狂野萤应助科研通管家采纳,获得20
34秒前
NexusExplorer应助科研通管家采纳,获得10
34秒前
Ava应助科研通管家采纳,获得10
34秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
2-Acetyl-1-pyrroline: an important aroma component of cooked rice 500
A real-time energy management strategy based on fuzzy control and ECMS for PHEVs 400
Handbook on People's China (1957) 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3189327
求助须知:如何正确求助?哪些是违规求助? 2838673
关于积分的说明 8021086
捐赠科研通 2501556
什么是DOI,文献DOI怎么找? 1335790
科研通“疑难数据库(出版商)”最低求助积分说明 637693
邀请新用户注册赠送积分活动 605784