Characterization of genomic regions escaping epigenetic reprogramming in sheep

重编程 表观遗传学 基因组印记 生物 DNA甲基化 遗传学 基因 基因表达
作者
Camila Urbano Braz,Matilde Maria Passamonti,Hasan Khatib
出处
期刊:Current Zoology [Oxford University Press]
卷期号:10 (1)
标识
DOI:10.1093/eep/dvad010
摘要

The mammalian genome undergoes two global epigenetic reprogramming events during the establishment of primordial germ cells and in the pre-implantation embryo after fertilization. These events involve the erasure and re-establishment of DNA methylation marks. However, imprinted genes and transposable elements (TEs) maintain their DNA methylation signatures to ensure normal embryonic development and genome stability. Despite extensive research in mice and humans, there is limited knowledge regarding environmentally induced epigenetic marks that escape epigenetic reprogramming in other species. Therefore, the objective of this study was to examine the characteristics and locations of genomic regions that evade epigenetic reprogramming in sheep, as well as to explore the biological functions of the genes within these regions. In a previous study, we identified 107 transgenerationally inherited differentially methylated cytosines (DMCs) in the F1 and F2 generations in response to a paternal methionine-supplemented diet. These DMCs were found in TEs, non-repetitive regions, and imprinted and non-imprinted genes. Our findings suggest that genomic regions, rather than TEs and imprinted genes, have the propensity to escape reprogramming and serve as potential candidates for transgenerational epigenetic inheritance. Notably, 34 transgenerational methylated genes influenced by paternal nutrition escaped reprogramming, impacting growth, development, male fertility, cardiac disorders, and neurodevelopment. Intriguingly, among these genes, 21 have been associated with neural development and brain disorders, such as autism, schizophrenia, bipolar disease, and intellectual disability. This suggests a potential genetic overlap between brain and infertility disorders. Overall, our study supports the concept of transgenerational epigenetic inheritance of environmentally induced marks in mammals.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
vivre223完成签到,获得积分10
3秒前
sysxxx发布了新的文献求助10
4秒前
xxxx完成签到 ,获得积分10
5秒前
Ava应助mbf采纳,获得10
7秒前
Shirley完成签到,获得积分10
7秒前
lezbj99发布了新的文献求助10
10秒前
可靠谷蓝完成签到 ,获得积分10
10秒前
北极星完成签到 ,获得积分10
12秒前
12秒前
sysxxx完成签到,获得积分10
13秒前
13秒前
桐桐应助三石采纳,获得10
14秒前
15秒前
16秒前
16秒前
小叮当完成签到,获得积分10
16秒前
务实土豆发布了新的文献求助10
17秒前
斯文败类应助惠JUI采纳,获得30
17秒前
猫大熊完成签到,获得积分10
18秒前
18秒前
张大炮发布了新的文献求助30
19秒前
22秒前
可爱的函函应助kaka采纳,获得10
22秒前
酷酷的笑白完成签到 ,获得积分10
22秒前
微笑世开完成签到 ,获得积分10
23秒前
24秒前
25秒前
艳艳子发布了新的文献求助10
27秒前
issl发布了新的文献求助10
28秒前
28秒前
george完成签到,获得积分10
28秒前
0000完成签到,获得积分20
29秒前
yjy完成签到,获得积分10
29秒前
chengchengzi完成签到,获得积分10
30秒前
31秒前
Vicky完成签到 ,获得积分10
31秒前
马麻薯完成签到,获得积分10
32秒前
幸运兔发布了新的文献求助10
32秒前
nn完成签到 ,获得积分10
32秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
2-Acetyl-1-pyrroline: an important aroma component of cooked rice 500
A real-time energy management strategy based on fuzzy control and ECMS for PHEVs 400
Handbook on People's China (1957) 400
2024 Medicinal Chemistry Reviews 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3190354
求助须知:如何正确求助?哪些是违规求助? 2839625
关于积分的说明 8024732
捐赠科研通 2502549
什么是DOI,文献DOI怎么找? 1336609
科研通“疑难数据库(出版商)”最低求助积分说明 637841
邀请新用户注册赠送积分活动 606051