Characterization of genomic regions escaping epigenetic reprogramming in sheep

重编程 表观遗传学 基因组印记 生物 DNA甲基化 遗传学 基因 基因表达
作者
Camila Urbano Braz,Matilde Maria Passamonti,Hasan Khatib
出处
期刊:Current Zoology [Oxford University Press]
卷期号:10 (1)
标识
DOI:10.1093/eep/dvad010
摘要

The mammalian genome undergoes two global epigenetic reprogramming events during the establishment of primordial germ cells and in the pre-implantation embryo after fertilization. These events involve the erasure and re-establishment of DNA methylation marks. However, imprinted genes and transposable elements (TEs) maintain their DNA methylation signatures to ensure normal embryonic development and genome stability. Despite extensive research in mice and humans, there is limited knowledge regarding environmentally induced epigenetic marks that escape epigenetic reprogramming in other species. Therefore, the objective of this study was to examine the characteristics and locations of genomic regions that evade epigenetic reprogramming in sheep, as well as to explore the biological functions of the genes within these regions. In a previous study, we identified 107 transgenerationally inherited differentially methylated cytosines (DMCs) in the F1 and F2 generations in response to a paternal methionine-supplemented diet. These DMCs were found in TEs, non-repetitive regions, and imprinted and non-imprinted genes. Our findings suggest that genomic regions, rather than TEs and imprinted genes, have the propensity to escape reprogramming and serve as potential candidates for transgenerational epigenetic inheritance. Notably, 34 transgenerational methylated genes influenced by paternal nutrition escaped reprogramming, impacting growth, development, male fertility, cardiac disorders, and neurodevelopment. Intriguingly, among these genes, 21 have been associated with neural development and brain disorders, such as autism, schizophrenia, bipolar disease, and intellectual disability. This suggests a potential genetic overlap between brain and infertility disorders. Overall, our study supports the concept of transgenerational epigenetic inheritance of environmentally induced marks in mammals.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
Lucas应助一棵树采纳,获得20
1秒前
2秒前
4秒前
努力搞科研完成签到,获得积分10
5秒前
英俊的铭应助冯哒哒采纳,获得10
5秒前
haonanchen完成签到,获得积分10
5秒前
淡淡的忆彤完成签到,获得积分10
6秒前
乐视薯片发布了新的文献求助10
7秒前
10秒前
上官若男应助whn采纳,获得10
10秒前
11秒前
标致的白桃完成签到 ,获得积分10
12秒前
苏幕遮完成签到,获得积分20
13秒前
jia完成签到 ,获得积分10
15秒前
16秒前
8R60d8应助包容的小蕊采纳,获得10
18秒前
19秒前
20秒前
深情安青应助hhhhhh采纳,获得10
20秒前
20秒前
21秒前
丘比特应助苏幕遮采纳,获得10
21秒前
22秒前
yyw完成签到 ,获得积分10
23秒前
郑宝发布了新的文献求助10
23秒前
田様应助AIA7采纳,获得10
24秒前
24秒前
25秒前
25秒前
Zorion发布了新的文献求助10
26秒前
雪落你看不见完成签到,获得积分10
26秒前
楠桉完成签到,获得积分10
27秒前
没有昵称完成签到 ,获得积分10
29秒前
逃之姚姚完成签到 ,获得积分10
29秒前
29秒前
32秒前
32秒前
耐心是生活的关键完成签到,获得积分10
33秒前
33秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Evolution 3rd edition 1500
保险藏宝图 1000
Lire en communiste 1000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3185860
求助须知:如何正确求助?哪些是违规求助? 2836182
关于积分的说明 8008180
捐赠科研通 2498578
什么是DOI,文献DOI怎么找? 1333656
科研通“疑难数据库(出版商)”最低求助积分说明 636907
邀请新用户注册赠送积分活动 604738