Characterization of genomic regions escaping epigenetic reprogramming in sheep

重编程 表观遗传学 基因组印记 生物 DNA甲基化 遗传学 基因 基因表达
作者
Camila Urbano Braz,Matilde Maria Passamonti,Hasan Khatib
出处
期刊:Current Zoology [Oxford University Press]
卷期号:10 (1)
标识
DOI:10.1093/eep/dvad010
摘要

The mammalian genome undergoes two global epigenetic reprogramming events during the establishment of primordial germ cells and in the pre-implantation embryo after fertilization. These events involve the erasure and re-establishment of DNA methylation marks. However, imprinted genes and transposable elements (TEs) maintain their DNA methylation signatures to ensure normal embryonic development and genome stability. Despite extensive research in mice and humans, there is limited knowledge regarding environmentally induced epigenetic marks that escape epigenetic reprogramming in other species. Therefore, the objective of this study was to examine the characteristics and locations of genomic regions that evade epigenetic reprogramming in sheep, as well as to explore the biological functions of the genes within these regions. In a previous study, we identified 107 transgenerationally inherited differentially methylated cytosines (DMCs) in the F1 and F2 generations in response to a paternal methionine-supplemented diet. These DMCs were found in TEs, non-repetitive regions, and imprinted and non-imprinted genes. Our findings suggest that genomic regions, rather than TEs and imprinted genes, have the propensity to escape reprogramming and serve as potential candidates for transgenerational epigenetic inheritance. Notably, 34 transgenerational methylated genes influenced by paternal nutrition escaped reprogramming, impacting growth, development, male fertility, cardiac disorders, and neurodevelopment. Intriguingly, among these genes, 21 have been associated with neural development and brain disorders, such as autism, schizophrenia, bipolar disease, and intellectual disability. This suggests a potential genetic overlap between brain and infertility disorders. Overall, our study supports the concept of transgenerational epigenetic inheritance of environmentally induced marks in mammals.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
ssssssssci完成签到,获得积分10
刚刚
hailang820316完成签到,获得积分10
1秒前
梅花鹿完成签到,获得积分10
1秒前
1秒前
武科大完成签到,获得积分10
1秒前
研友_pnxBe8发布了新的文献求助10
1秒前
闪闪星星完成签到,获得积分10
2秒前
灵巧晓山完成签到,获得积分10
3秒前
jax发布了新的文献求助10
3秒前
4秒前
自然白亦完成签到,获得积分10
4秒前
xiaochouyu完成签到,获得积分10
4秒前
4秒前
珂珂子完成签到,获得积分10
4秒前
5秒前
lorentzh完成签到,获得积分10
5秒前
寻道图强应助yeye采纳,获得30
5秒前
自渡完成签到 ,获得积分10
5秒前
无情寒珊发布了新的文献求助10
6秒前
sai完成签到,获得积分10
6秒前
cxy完成签到,获得积分10
7秒前
7秒前
Orange应助mimi采纳,获得10
7秒前
saxg_hu完成签到,获得积分10
7秒前
俭朴的寇完成签到,获得积分10
8秒前
LHZ完成签到,获得积分10
8秒前
ckz完成签到,获得积分10
8秒前
111发布了新的文献求助10
9秒前
小风吹着发布了新的文献求助10
9秒前
SDFSGFDR发布了新的文献求助10
10秒前
xqq完成签到,获得积分10
10秒前
10秒前
镜月完成签到 ,获得积分10
10秒前
圆圆的分子球完成签到 ,获得积分10
10秒前
12秒前
星辰大海应助l玖采纳,获得10
12秒前
隐形曼青应助邓鹏煊采纳,获得10
12秒前
12秒前
乐正念云完成签到,获得积分10
12秒前
Amz完成签到,获得积分20
12秒前
高分求助中
Evolution 3rd edition 1500
保险藏宝图 1000
Lire en communiste 1000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3183799
求助须知:如何正确求助?哪些是违规求助? 2833984
关于积分的说明 7996675
捐赠科研通 2496268
什么是DOI,文献DOI怎么找? 1332000
科研通“疑难数据库(出版商)”最低求助积分说明 636519
邀请新用户注册赠送积分活动 603665