Characterization of genomic regions escaping epigenetic reprogramming in sheep

重编程 表观遗传学 基因组印记 生物 DNA甲基化 遗传学 基因 基因表达
作者
Camila Urbano Braz,Matilde Maria Passamonti,Hasan Khatib
出处
期刊:Current Zoology [Oxford University Press]
卷期号:10 (1)
标识
DOI:10.1093/eep/dvad010
摘要

The mammalian genome undergoes two global epigenetic reprogramming events during the establishment of primordial germ cells and in the pre-implantation embryo after fertilization. These events involve the erasure and re-establishment of DNA methylation marks. However, imprinted genes and transposable elements (TEs) maintain their DNA methylation signatures to ensure normal embryonic development and genome stability. Despite extensive research in mice and humans, there is limited knowledge regarding environmentally induced epigenetic marks that escape epigenetic reprogramming in other species. Therefore, the objective of this study was to examine the characteristics and locations of genomic regions that evade epigenetic reprogramming in sheep, as well as to explore the biological functions of the genes within these regions. In a previous study, we identified 107 transgenerationally inherited differentially methylated cytosines (DMCs) in the F1 and F2 generations in response to a paternal methionine-supplemented diet. These DMCs were found in TEs, non-repetitive regions, and imprinted and non-imprinted genes. Our findings suggest that genomic regions, rather than TEs and imprinted genes, have the propensity to escape reprogramming and serve as potential candidates for transgenerational epigenetic inheritance. Notably, 34 transgenerational methylated genes influenced by paternal nutrition escaped reprogramming, impacting growth, development, male fertility, cardiac disorders, and neurodevelopment. Intriguingly, among these genes, 21 have been associated with neural development and brain disorders, such as autism, schizophrenia, bipolar disease, and intellectual disability. This suggests a potential genetic overlap between brain and infertility disorders. Overall, our study supports the concept of transgenerational epigenetic inheritance of environmentally induced marks in mammals.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
慕青应助Zakry采纳,获得10
1秒前
FashionBoy应助专一的青槐采纳,获得10
1秒前
2秒前
罗罗发布了新的文献求助20
4秒前
李爱国应助啦啦啦采纳,获得10
5秒前
兴奋的小虾米完成签到,获得积分10
5秒前
ZCP发布了新的文献求助10
5秒前
简单绯完成签到,获得积分10
6秒前
初心发布了新的文献求助10
7秒前
7秒前
大聪明完成签到,获得积分10
7秒前
pengliao完成签到,获得积分10
7秒前
英俊的铭应助陌上尘采纳,获得10
7秒前
9秒前
9秒前
俱乐部发布了新的文献求助10
12秒前
隐形曼青应助一朵云采纳,获得10
12秒前
RRR发布了新的文献求助10
13秒前
等待的谷波完成签到 ,获得积分10
13秒前
高贵以珊完成签到,获得积分10
13秒前
科研通AI2S应助花漾采纳,获得10
14秒前
15秒前
烂漫碧玉完成签到,获得积分10
16秒前
16秒前
Lucas应助初心采纳,获得10
17秒前
18秒前
18秒前
19秒前
不配.应助小周同学采纳,获得10
19秒前
20秒前
20秒前
赘婿应助ZCP采纳,获得10
22秒前
自由初夏发布了新的文献求助10
23秒前
23秒前
hhh关闭了hhh文献求助
23秒前
24秒前
俱乐部完成签到,获得积分10
24秒前
25秒前
25秒前
zz发布了新的文献求助10
26秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Evolution 3rd edition 1500
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3188290
求助须知:如何正确求助?哪些是违规求助? 2837794
关于积分的说明 8017206
捐赠科研通 2500478
什么是DOI,文献DOI怎么找? 1334942
科研通“疑难数据库(出版商)”最低求助积分说明 637363
邀请新用户注册赠送积分活动 605381