Characterization of genomic regions escaping epigenetic reprogramming in sheep

重编程 表观遗传学 基因组印记 生物 DNA甲基化 遗传学 基因 基因表达
作者
Camila Urbano Braz,Matilde Maria Passamonti,Hasan Khatib
出处
期刊:Current Zoology [Oxford University Press]
卷期号:10 (1)
标识
DOI:10.1093/eep/dvad010
摘要

The mammalian genome undergoes two global epigenetic reprogramming events during the establishment of primordial germ cells and in the pre-implantation embryo after fertilization. These events involve the erasure and re-establishment of DNA methylation marks. However, imprinted genes and transposable elements (TEs) maintain their DNA methylation signatures to ensure normal embryonic development and genome stability. Despite extensive research in mice and humans, there is limited knowledge regarding environmentally induced epigenetic marks that escape epigenetic reprogramming in other species. Therefore, the objective of this study was to examine the characteristics and locations of genomic regions that evade epigenetic reprogramming in sheep, as well as to explore the biological functions of the genes within these regions. In a previous study, we identified 107 transgenerationally inherited differentially methylated cytosines (DMCs) in the F1 and F2 generations in response to a paternal methionine-supplemented diet. These DMCs were found in TEs, non-repetitive regions, and imprinted and non-imprinted genes. Our findings suggest that genomic regions, rather than TEs and imprinted genes, have the propensity to escape reprogramming and serve as potential candidates for transgenerational epigenetic inheritance. Notably, 34 transgenerational methylated genes influenced by paternal nutrition escaped reprogramming, impacting growth, development, male fertility, cardiac disorders, and neurodevelopment. Intriguingly, among these genes, 21 have been associated with neural development and brain disorders, such as autism, schizophrenia, bipolar disease, and intellectual disability. This suggests a potential genetic overlap between brain and infertility disorders. Overall, our study supports the concept of transgenerational epigenetic inheritance of environmentally induced marks in mammals.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
秀xiu完成签到,获得积分10
7秒前
柏忆南完成签到 ,获得积分10
14秒前
even完成签到 ,获得积分10
15秒前
WeMeH完成签到 ,获得积分10
19秒前
19秒前
chenman9397完成签到 ,获得积分10
26秒前
27秒前
大呲花完成签到,获得积分10
34秒前
wang完成签到,获得积分10
40秒前
Herbs完成签到 ,获得积分10
48秒前
mojomars完成签到,获得积分10
50秒前
hhh2018687完成签到,获得积分10
52秒前
56秒前
1分钟前
kmzzy完成签到,获得积分10
1分钟前
1分钟前
虚拟的尔蓝完成签到 ,获得积分10
1分钟前
xkhxh完成签到 ,获得积分10
1分钟前
ZZ0110Z完成签到 ,获得积分10
1分钟前
六六完成签到 ,获得积分10
1分钟前
没时间解释了完成签到 ,获得积分10
1分钟前
chenbin完成签到,获得积分10
1分钟前
yupingqin完成签到 ,获得积分10
1分钟前
Jonsnow完成签到 ,获得积分10
1分钟前
陈米花完成签到,获得积分10
1分钟前
yyjl31完成签到,获得积分0
1分钟前
Simon_chat完成签到,获得积分10
1分钟前
吐司炸弹完成签到,获得积分10
1分钟前
mayfly完成签到,获得积分10
1分钟前
yelv123完成签到,获得积分20
1分钟前
百合完成签到 ,获得积分10
1分钟前
leezhen完成签到,获得积分10
1分钟前
清爽的火车完成签到 ,获得积分10
1分钟前
轩辕中蓝完成签到 ,获得积分10
1分钟前
诺亚方舟哇哈哈完成签到 ,获得积分0
1分钟前
七月星河完成签到 ,获得积分10
1分钟前
junxi完成签到 ,获得积分20
1分钟前
莎莎完成签到 ,获得积分10
1分钟前
崩溃完成签到,获得积分10
2分钟前
远山完成签到 ,获得积分10
2分钟前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Aspects of Babylonian celestial divination: the lunar eclipse tablets of Enūma Anu Enlil 500
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
Dictionary of socialism 350
Mixed-anion Compounds 300
Geochemistry, 2nd Edition 地球化学经典教科书第二版 300
Idoxuridine 260
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3196852
求助须知:如何正确求助?哪些是违规求助? 2845505
关于积分的说明 8054331
捐赠科研通 2510132
什么是DOI,文献DOI怎么找? 1342314
科研通“疑难数据库(出版商)”最低求助积分说明 639355
邀请新用户注册赠送积分活动 608669