Characterization of genomic regions escaping epigenetic reprogramming in sheep

重编程 表观遗传学 基因组印记 生物 DNA甲基化 遗传学 基因 基因表达
作者
Camila Urbano Braz,Matilde Maria Passamonti,Hasan Khatib
出处
期刊:Current Zoology [Oxford University Press]
卷期号:10 (1)
标识
DOI:10.1093/eep/dvad010
摘要

The mammalian genome undergoes two global epigenetic reprogramming events during the establishment of primordial germ cells and in the pre-implantation embryo after fertilization. These events involve the erasure and re-establishment of DNA methylation marks. However, imprinted genes and transposable elements (TEs) maintain their DNA methylation signatures to ensure normal embryonic development and genome stability. Despite extensive research in mice and humans, there is limited knowledge regarding environmentally induced epigenetic marks that escape epigenetic reprogramming in other species. Therefore, the objective of this study was to examine the characteristics and locations of genomic regions that evade epigenetic reprogramming in sheep, as well as to explore the biological functions of the genes within these regions. In a previous study, we identified 107 transgenerationally inherited differentially methylated cytosines (DMCs) in the F1 and F2 generations in response to a paternal methionine-supplemented diet. These DMCs were found in TEs, non-repetitive regions, and imprinted and non-imprinted genes. Our findings suggest that genomic regions, rather than TEs and imprinted genes, have the propensity to escape reprogramming and serve as potential candidates for transgenerational epigenetic inheritance. Notably, 34 transgenerational methylated genes influenced by paternal nutrition escaped reprogramming, impacting growth, development, male fertility, cardiac disorders, and neurodevelopment. Intriguingly, among these genes, 21 have been associated with neural development and brain disorders, such as autism, schizophrenia, bipolar disease, and intellectual disability. This suggests a potential genetic overlap between brain and infertility disorders. Overall, our study supports the concept of transgenerational epigenetic inheritance of environmentally induced marks in mammals.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
2秒前
guangshuang发布了新的文献求助10
4秒前
东东呀完成签到,获得积分10
5秒前
dd发布了新的文献求助10
5秒前
半夏发布了新的文献求助10
5秒前
archer01发布了新的文献求助10
5秒前
天天快乐应助菜菜带带采纳,获得10
5秒前
翊瑾发布了新的文献求助10
6秒前
6秒前
6秒前
顾矜应助kb采纳,获得10
6秒前
bkagyin应助科研通管家采纳,获得10
6秒前
大模型应助科研通管家采纳,获得10
6秒前
田様应助科研通管家采纳,获得10
6秒前
无花果应助科研通管家采纳,获得10
7秒前
NexusExplorer应助科研通管家采纳,获得10
7秒前
7秒前
李爱国应助科研通管家采纳,获得10
7秒前
7秒前
7秒前
开放的素发布了新的文献求助10
7秒前
TORCH发布了新的文献求助10
9秒前
可爱的函函应助程院采纳,获得10
9秒前
10秒前
小马甲应助Amber采纳,获得10
11秒前
lalala应助健壮凡桃采纳,获得10
12秒前
YY发布了新的文献求助10
12秒前
出其东门发布了新的文献求助10
13秒前
IN完成签到,获得积分10
14秒前
15秒前
NexusExplorer应助younan采纳,获得10
15秒前
这学真难读下去完成签到,获得积分10
16秒前
半柚完成签到,获得积分20
17秒前
17秒前
17秒前
zz发布了新的文献求助10
18秒前
18秒前
上官若男应助RolfHoward采纳,获得10
18秒前
SciGPT应助半截神经病采纳,获得10
19秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Write Like a Chemist: A Guide and Resource (第二版) 600
Mixed-anion Compounds 600
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
Earth System Geophysics 500
Aspects of Babylonian celestial divination: the lunar eclipse tablets of Enūma Anu Enlil 500
Geochemistry, 2nd Edition 地球化学经典教科书第二版 401
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3200070
求助须知:如何正确求助?哪些是违规求助? 2849818
关于积分的说明 8070095
捐赠科研通 2513658
什么是DOI,文献DOI怎么找? 1346482
科研通“疑难数据库(出版商)”最低求助积分说明 640227
邀请新用户注册赠送积分活动 610102