外周血单个核细胞
衣壳
免疫系统
免疫疗法
人乳头瘤病毒
医学
外周血
免疫学
癌症研究
病毒
化学
内科学
体外
生物化学
作者
Camille Jacques,Françoise Marchand,Mathias Chatelais,Virginie Albinet,Claire Coustal,Ilaria Floris
出处
期刊:Cancers
[MDPI AG]
日期:2024-04-05
卷期号:16 (7): 1421-1421
标识
DOI:10.3390/cancers16071421
摘要
Human papillomavirus (HPV) is the second most common infectious agent causing cancer. Persistent infection with high-risk (HR)-HPV can lead to cervical intra-epithelial neoplasia and cervical carcinomas (CC). While host immune response is necessary for viral clearance, chronic immune activation contributes to a low-grade inflammation that can ultimately lead to carcinogenesis. The micro-immunotherapy medicine (MIM) 2LPAPI® could be a valuable tool to manage the clearance of the virus and reduce the risk of developing CC. In this in vitro study, we aimed to investigate its mode of action. We showed that actives from the MIM increased the IL-6, IFN-γ, and IP-10 secretion in human peripheral blood mononuclear cells (PBMCs) exposed to peptides derived from the HPV-16 capsid (HPV16(L1)). This could reflect an increase in the immune activity toward HPV-16. At the same time, some active substances reduced the lympho-proliferation and the expression of T-cell activation markers. Finally, some of the MIM actives displayed antiproliferative effects in CC-derived HeLa cells under serum-starvation conditions. Altogether, this body of data highlighted for the first time the dual effect of MIM in the framework of HR-HPV infections as a potential (i) immune modulator of HPV16(L1)-treated PBMCs and (ii) antiproliferative agent of HPV-positive CC cells.
科研通智能强力驱动
Strongly Powered by AbleSci AI