清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Chinese herbal medicines for the treatment of depression: a systematic review and network meta-analysis

医学 传统医学 不利影响 汤剂 科克伦图书馆 萧条(经济学) 荟萃分析 舍曲林 哈姆德 内科学 抗抑郁药 经济 宏观经济学 显著性差异 海马体
作者
Chun Dang,Qinxuan Wang,Qian Li,Ying Xiong,Yaoheng Lu
出处
期刊:Frontiers in Pharmacology [Frontiers Media]
卷期号:15
标识
DOI:10.3389/fphar.2024.1295564
摘要

Objectives: Amidst rising global burden of depression and the associated challenges with conventional antidepressant therapies, there is a growing interest in exploring the efficacy and safety of alternative treatments. This study uses a Bayesian network meta-analysis to rigorously evaluate the therapeutic potential of Chinese herbal medicines in the treatment of depression, focusing on their comparative efficacy and safety against standard pharmacological interventions. Methods: Five databases (PubMed, Wanfang Data, EMBASE, CNKI, and the Cochrane Library) and grey literature were searched from inception to end of July 2023 to identify studies that assessed the efficacy and safety of Chinese herbal medicines in treating depression. The response rate, Hamilton Depression Scale (HAMD) scores, and rates of adverse events were assessed through both direct and indirect comparisons. Data extraction and risk of bias assessment were meticulously performed. Statistical analysis used Markov chain Monte Carlo methods, with effect size estimates provided as odd ratios and their 95% confidence intervals. Results: A total of 198 RCTs involving 8,923 patients were analyzed, assessing 17 Chinese herbal medicines. Surface Under the Cumulative Ranking results indicated that the top three treatments with the best response rate were possibly Guipiwan , Ease Pill , and Chaihu Jia Longgu Muli Decoction ; the top three treatments on the reduction of HAMD scores were Chai Hu Shu Gan San , Xingnao Jieyu Decoction , and Xiaoyao Powder ; and the top three treatments with the lowest adverse effects rates were Xiaoyao Powder , Alprazolam , and Xingnao Jieyu Decoction . Interestingly, commonly used synthetic drugs such as Fluoxetine , Escitalopram , Amitriptyline , Sertraline , Flupentixol and Melitracen , and Venlafaxine , not only appeared to be less effective than specific Chinese herbal medicines ( Gan Mai Da Zao Decoction , Chaihu Jia Longgu Muli Decoction , Chai Hu Shu Gan San , Danzhi-Xiaoyao-San , and Xingnao Jieyu Decoction ), but they were also related to substantially higher risk of adverse events. Conclusion: Our findings elucidate the promising therapeutic potential of Chinese herbal medicines as viable alternatives in the treatment of depression, with certain herbs demonstrating enhanced efficacy and safety profiles. The outcomes of this study advocate for the integration of these alternative modalities into contemporary depression management paradigms. However, it underscores the necessity for larger, methodologically robust trials to further validate and refine these preliminary findings. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/ , identifier CRD42023452109.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
FashionBoy应助康康XY采纳,获得30
11秒前
科研通AI2S应助科研通管家采纳,获得10
13秒前
16秒前
蓝天阳光完成签到,获得积分10
23秒前
25秒前
1分钟前
量子星尘发布了新的文献求助10
1分钟前
科研通AI2S应助chenqi采纳,获得10
1分钟前
1分钟前
白天亮完成签到,获得积分10
1分钟前
完美世界应助科研通管家采纳,获得10
2分钟前
科研通AI2S应助科研通管家采纳,获得10
2分钟前
Owen应助科研通管家采纳,获得10
2分钟前
Owen应助科研通管家采纳,获得10
2分钟前
Glitter完成签到 ,获得积分10
2分钟前
00完成签到 ,获得积分10
2分钟前
量子星尘发布了新的文献求助10
3分钟前
3分钟前
康康XY发布了新的文献求助30
3分钟前
3分钟前
3分钟前
研友_8y2G0L完成签到,获得积分10
4分钟前
mathmotive完成签到,获得积分20
4分钟前
双手外科结完成签到,获得积分10
4分钟前
4分钟前
量子星尘发布了新的文献求助10
4分钟前
4分钟前
梵莫发布了新的文献求助10
4分钟前
4分钟前
nojego完成签到,获得积分10
4分钟前
5分钟前
量子星尘发布了新的文献求助10
5分钟前
5分钟前
6分钟前
梵莫发布了新的文献求助10
6分钟前
深情安青应助科研通管家采纳,获得10
6分钟前
6分钟前
量子星尘发布了新的文献求助10
6分钟前
CodeCraft应助康康XY采纳,获得10
6分钟前
无一完成签到 ,获得积分0
7分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Immigrant Incorporation in East Asian Democracies 600
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3972811
求助须知:如何正确求助?哪些是违规求助? 3517116
关于积分的说明 11186225
捐赠科研通 3252713
什么是DOI,文献DOI怎么找? 1796589
邀请新用户注册赠送积分活动 876487
科研通“疑难数据库(出版商)”最低求助积分说明 805701