粒体自噬
线粒体
线粒体融合
先天免疫系统
生物
脂肪性肝炎
线粒体分裂
酒精性肝病
细胞生物学
线粒体DNA
脂肪肝
细胞内
癌症研究
免疫系统
免疫学
医学
细胞凋亡
疾病
自噬
肝硬化
遗传学
内科学
基因
作者
Xiaowen Ma,Mengwei Niu,Hong‐Min Ni,Wen–Xing Ding
标识
DOI:10.1097/hep.0000000000000910
摘要
Mitochondria are intracellular organelles responsible for energy production, glucose and lipid metabolism, cell death, cell proliferation, and innate immune response. Mitochondria are highly dynamic organelles that constantly undergo fission, fusion, and intracellular trafficking, as well as degradation and biogenesis. Mitochondrial dysfunction has been implicated in a variety of chronic liver diseases including alcohol-associated liver disease (ALD), metabolic dysfunction-associated steatohepatitis (MASH), and hepatocellular carcinoma (HCC). In this review, we provide a detailed overview of mitochondrial dynamics, mitophagy, and mtDNA-mediated innate immune response, and how dysregulation of these mitochondrial processes affects the pathogenesis of ALD and HCC. Mitochondrial dynamics and mtDNA-mediated innate immune response may thereby represent an attractive therapeutic target for ameliorating ALD and alcohol-associated HCC.
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