[Comparison of time series and case-crossover analyses in environmental epidemiology].

Time-series and case-crossover are two main study designs in environmental epidemiology. However, due to the differences in design principles and model construction between the two analyses, the results of the two analyses may not be consistent. Herein, we examined the short-term effect of cold spells on cardiovascular mortality in Nanjing using both time series and case-crossover analyses, aiming to provide a basis for the selection of appropriate research design in environmental epidemiology.时间序列和病例交叉是环境流行病学研究常用的两种方法，由于两种方法在设计原理和模型构建等方面存在差异，所得出的结论可能并不完全一致。本文以南京市气象和人群心血管病死亡数据为基础资料，分别应用时间序列和病例交叉方法分析寒潮对心血管病死亡的短期效应，为今后在环境与健康研究中选择合适的研究方法提供参考。.