阿卡波糖
黄芪甲素
化学
传统医学
糖苷
芹菜素
类黄酮
IC50型
抗氧化剂
药理学
体外
生物活性化合物
生物化学
医学
酶
立体化学
山奈酚
作者
Nanda Lega Jaya Putra,Afrillia Nuryanti Garmana,Nurinanda Prisky Qomaladewi,Amrianto,Laode Muhammad Ramadhan Al Muqarrabun,Andi Rifki Rosandy,Agus Chahyadi,Muhamad Insanu,Elfahmi Elfahmi
标识
DOI:10.1016/j.scp.2022.100907
摘要
Naturally-derived antidiabetic medications have been explored as alternatives to the current widely-used drugs which can cause mild to severe side effects. Sauropus androgynus has been traditionally utilized to treat diabetes patients. In this report, a flavonoid glycoside, astragalin (1), was isolated from the leaves extract of S. androgynus using bioassay-guided isolation approach. Enrichment processes using macroporous resins resulted in two enriched fractions with 1 contents of 0.083% and 0.054% for PAD610 and PAD900 fractions, respectively. Compound 1 showed a higher α-glucosidase inhibitory (IC50 = 55.03 ± 0.61 μg/mL) than that of acarbose. In vitro assay for antioxidant and α-glucosidase inhibitory activities showed the greatest inhibition by PAD 610 fractions which has 98.912% and 83.268%, respectively. These findings have shown promising results for further studies on S. androgynus as a potential herbal drug, particularly for the treatment of diabetes.
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