室下区
神经干细胞
亚颗粒带
干细胞
胚胎干细胞
神经科学
神经上皮细胞
诱导多能干细胞
神经发生
医学
祖细胞
干细胞疗法
齿状回
成体干细胞
生物
海马体
细胞生物学
生物化学
基因
作者
Cezary Grochowski,Elżbieta Radzikowska,Ryszard Maciejewski
标识
DOI:10.1016/j.clineuro.2018.07.013
摘要
Adult mammalian neural stem cells are unique because of their properties, such as differentiation capacity, self-renewal, quiescence, and also because they exist in specific niches, which are the subventricular zone (SVZ) and subgranular zone (SGZ) - the dentate gyrus of the hippocampus. SVZ is situated along the ependymal cell layer, dividing the ventricular area and subventricular zone. There are several sources of neural stem cells such as human embryonic stem cells, human fetal brain-derived neural stem/progenitor cells, human induced pluripotent stem cells, direct reprogrammed astrocytes. Stem cell sciences are a promising tool for research purposes as well as therapy. Induced pluripotent stem cells appear to be very useful for human neuron studies, allowing the creation of defined neuron populations, particularly for neurodevelopmental and neurodegenerative diseases as well as ischemic events. Neural stem cell sciences have a promising future in terms of stem cell therapy as well as research. There is, however, still a great need for further research to overcome obstacles.
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