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Magnetic Glycol Chitin-Based Hydrogel Nanocomposite for Combined Thermal and d-Amino-Acid-Assisted Biofilm Disruption

生物膜 纳米复合材料 氨基酸 磁性纳米粒子 甲壳素 抗菌剂 材料科学 化学 纳米颗粒 胞外聚合物 微生物学 纳米技术 化学工程 壳聚糖 细菌 生物化学 生物 有机化学 工程类 遗传学
作者
Eric Abenojar,Sameera Wickramasinghe,Minseon Ju,Sarika Uppaluri,Alison K. Klika,Jaiben George,Wael K. Barsoum,Salvatore J. Frangiamore,Carlos A. Higuera,Anna Cristina S. Samia
出处
期刊:ACS Infectious Diseases [American Chemical Society]
卷期号:4 (8): 1246-1256 被引量:35
标识
DOI:10.1021/acsinfecdis.8b00076
摘要

Bacterial biofilms are highly antibiotic resistant microbial cell associations that lead to chronic infections. Unlike free-floating planktonic bacterial cells, the biofilms are encapsulated in a hardly penetrable extracellular polymeric matrix and, thus, demand innovative approaches for treatment. Recent advancements on the development of gel-nanocomposite systems with tailored therapeutic properties provide promising routes to develop novel antimicrobial agents that can be designed to disrupt and completely eradicate preformed biofilms. In our study, we developed a unique thermoresponsive magnetic glycol chitin-based nanocomposite containing d-amino acids and iron oxide nanoparticles, which can be delivered and undergoes transformation from a solution to a gel state at physiological temperature for sustained release of d-amino acids and magnetic field actuated thermal treatment of targeted infection sites. The d-amino acids in the hydrogel nanocomposite have been previously reported to inhibit biofilm formation and also disrupt existing biofilms. In addition, loading the hydrogel nanocomposite with magnetic nanoparticles allows for combination thermal treatment following magnetic field (magnetic hyperthermia) stimulation. Using this novel two-step approach to utilize an externally actuated gel-nanocomposite system for thermal treatment, following initial disruption with d-amino acids, we were able to demonstrate in vitro the total eradication of Staphylococcus aureus biofilms, which were resistant to conventional antibiotics and were not completely eradicated by separate d-amino acid or magnetic hyperthermia treatments.
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