神经母细胞瘤
多胺
癌症研究
肿瘤进展
化学
医学
生物
药理学
内科学
癌症
细胞培养
生物化学
遗传学
作者
Laura D. Gamble,Stefania Purgato,Jayne Murray,Lin Xiao,Denise Yu,Kimberley M. Hanssen,Federico M. Giorgi,Daniel R. Carter,Andrew J. Gifford,Emanuele Valli,Giorgio Milazzo,Alvin Kamili,Chelsea Mayoh,Bing Liu,Georgina L. Eden,Sara Sarraf,Sophie Allan,Simone Di Giacomo,Claudia L. Flemming,Amanda J. Russell
标识
DOI:10.1126/scitranslmed.aau1099
摘要
MYCN regulates polyamines in neuroblastoma, and combined inhibition of polyamine synthesis and transport has therapeutic effects in mouse models.
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