Diagnosis and management of primary immune thrombocytopenia in adults

British Journal of Hospital MedicineVol. 80, No. 4 Core Training For DoctorsDiagnosis and management of primary immune thrombocytopenia in adultsAyesha Ejaz, Deepti RadiaAyesha EjazCorrespondence to: Dr A Ejaz (E-mail Address: [email protected])Haematology Clinical Fellow, Department of Haematology, Guy's and St Thomas' Hospital, London SE1 9RT, Deepti Radiaonsultant Haematologist, Department of Haematology, Guy's and St Thomas' Hospital, LondonAyesha Ejaz; Deepti RadiaPublished Online:5 Apr 2019https://doi.org/10.12968/hmed.2019.80.4.C54AboutSectionsView articleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareShare onFacebookTwitterLinked InEmail View article References Arnold DM, Dentali F, Crowther MA et al.. Systematic review: efficacy and safety of rituximab for adults with idiopathic thrombocytopenic purpura. Ann Intern Med. 2007 Jan 02;146(1):25–33. https://doi.org/10.7326/0003-4819-146-1-200701020-00006 Crossref, Medline, Google ScholarBritish Committee for Standards in Haematology General Haematology Task Force. Guidelines for the investigation and management of idiopathic thrombocytopenic purpura in adults, children and in pregnancy. Br J Haematol. 2003 Feb;120(4):574–596. https://doi.org/10.1046/j.1365-2141.2003.04131.x Crossref, Medline, Google ScholarCatalá-López F, Corrales I, de la Fuente-Honrubia C, González-Bermejo D, Martín-Serrano G, Montero D, Saint-Gerons DM. Risk of thromboembolism with thrombopoietin receptor agonists in adult patients with thrombocytopenia: systematic review and meta-analysis of randomized controlled trials. Med Clin (Barc). 2015 Dec;145(12):511–519. https://doi.org/10.1016/j.medcli.2015.03.014 Crossref, Medline, Google ScholarCooper N, Radia D. State of the art - how I manage immune thrombocytopenia. Br J Haematol. 2017 Apr;177(1):39–54. https://doi.org/10.1111/bjh.14515 Crossref, Medline, Google ScholarEstcourt LJ, Birchall J, Allard S et al.; British Committee for Standards in Haematology. Guidelines for the use of platelet transfusions. Br J Haematol. 2017 Feb;176(3):365–394. https://doi.org/10.1111/bjh.14423 Crossref, Medline, Google ScholarFogarty PF. Chronic immune thrombocytopenia in adults: epidemiology and clinical presentation. Hematol Oncol Clin North Am. 2009 Dec;23(6):1213–1221. https://doi.org/10.1016/j.hoc.2009.08.004 Crossref, Medline, Google ScholarGhanima W, Godeau B, Cines DB, Bussel JB. How I treat immune thrombocytopenia: the choice between splenectomy or a medical therapy as a second-line treatment. Blood. 2012 Aug 02;120(5):960–969. https://doi.org/10.1182/blood-2011-12-309153 Crossref, Medline, Google ScholarLambert MP, Gernsheimer TB. Clinical updates in adult immune thrombocytopenia. Blood. 2017 May 25;129(21):2829–2835. https://doi.org/10.1182/blood-2017-03-754119 Crossref, Medline, Google ScholarMatschke J, Müller-Beissenhirtz H, Novotny J et al.. A randomized trial of daily prednisone versus pulsed dexamethasone in treatment-naïve adult patients with immune thrombocytopenia: EIS 2002 study. Acta Haematol. 2016;136(2):101–107. https://doi.org/10.1159/000445420 Crossref, Medline, Google ScholarNeunert C, Lim W, Crowther M, Cohen A, Solberg L Jr, Crowther MA; American Society of Hematology. The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia. Blood. 2011 Apr 21;117(16):4190–4207. https://doi.org/10.1182/blood-2010-08-302984 Crossref, Medline, Google ScholarPell J, Greenwood R, Ingram J et al.. Trial protocol: a multicentre randomised trial of first-line treatment pathways for newly diagnosed immune thrombocytopenia: standard steroid treatment versus combined steroid and mycophenolate. The FLIGHT trial. BMJ Open. 2018 Oct;8(10):e024427. https://doi.org/10.1136/bmjopen-2018-024427 Crossref, Medline, Google ScholarProvan D, Stasi R, Newland AC et al.. International consensus report on the investigation and management of primary immune thrombocytopenia. Blood. 2010 Jan 14;115(2):168–186. https://doi.org/10.1182/blood-2009-06-225565 Crossref, Medline, Google ScholarTaylor A, Westwood JP, Laskou F, McGuckin S, Scully M. Thrombopoetin receptor agonist therapy in thrombocytopenia: ITP and beyond. Br J Haematol. 2017 May;177(3):475–480. https://doi.org/10.1111/bjh.14564 Crossref, Medline, Google Scholar FiguresReferencesRelatedDetails 2 April 2019Volume 80Issue 4ISSN (print): 1750-8460ISSN (online): 1759-7390 Metrics History Published online 5 April 2019 Published in print 2 April 2019 Information© MA Healthcare LimitedPDF download