Spatial Patterns From High-Resolution Electrogastrography Correlate With Severity of Symptoms in Patients With Functional Dyspepsia and Gastroparesis

胃轻瘫 医学 胃排空 内科学 胃肠病学 高分辨率测压 回流 疾病
作者
Armen A. Gharibans,Todd P. Coleman,Hayat Mousa,David C. Kunkel
出处
期刊:Clinical Gastroenterology and Hepatology [Elsevier]
卷期号:17 (13): 2668-2677 被引量:109
标识
DOI:10.1016/j.cgh.2019.04.039
摘要

Invasive gastric electrical mapping has revealed spatial abnormalities of the slow wave in subjects with gastroparesis and functional gastrointestinal disorders. Cutaneous high-resolution electrogastrography (HR-EGG) is a non-invasive method that can detect spatial features of the gastric slow wave. We performed HR-EGG in subjects with active foregut symptoms to evaluate associations between gastric myoelectric abnormalities, symptoms (based on a validated questionnaire), and gastric emptying.We performed a case-control study of 32 subjects, including 7 healthy individuals (controls), 7 subjects with functional dyspepsia and normal gastric emptying, and 18 subjects with gastroparesis, from a tertiary care program. All subjects were assessed by computed tomography imaging of the abdomen and HR-EGG and completed the PAGI-SYM questionnaire on foregut symptoms, which includes the gastroparesis cardinal symptom index. We performed volume reconstruction of the torso and stomach from computed tomography images to guide accurate placement of the HR-EGG array.Spatial slow-wave abnormalities were detected in 44% of subjects with foregut symptoms. Moreover, subjects with a higher percentage of slow waves with aberrant propagation direction had a higher total gastroparesis cardinal symptom index score (r = 0.56; P < .001) and more severe abdominal pain (r = 0.46; P = .009). We found no correlation between symptoms and traditional EGG parameters.In case-control study, we found that the genesis of symptoms of functional dyspepsia and gastroparesis is likely multifactorial, including possible contribution from gastric myoelectric dysfunction. Abnormal spatial parameters, detected by cutaneous HR-EGG, correlated with severity of upper gastrointestinal symptoms, regardless of gastric emptying. This noninvasive, repeatable approach might be used to identify patients for whom gastric myoelectric dysfunction contributes to functional dyspepsia and gastroparesis.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
广隶完成签到,获得积分20
刚刚
huan9955完成签到,获得积分10
1秒前
大个应助liyuxuan采纳,获得10
2秒前
Sharkshain关注了科研通微信公众号
3秒前
xing完成签到,获得积分10
3秒前
5秒前
5秒前
Eton完成签到,获得积分10
5秒前
mito发布了新的文献求助200
6秒前
干净的夏天完成签到,获得积分10
7秒前
橙子完成签到,获得积分10
10秒前
西西弗斯完成签到,获得积分10
11秒前
加贝完成签到 ,获得积分10
12秒前
思源应助默默采纳,获得10
12秒前
12秒前
GGBond完成签到,获得积分10
13秒前
鳗鱼灵安完成签到,获得积分10
13秒前
humorlife完成签到,获得积分10
14秒前
慕寒完成签到,获得积分10
14秒前
JPL3729完成签到,获得积分10
15秒前
糖醋鱼完成签到,获得积分10
15秒前
zhishiyanhua发布了新的文献求助30
15秒前
科目三应助WHY采纳,获得10
15秒前
可可可11完成签到 ,获得积分10
17秒前
YY完成签到,获得积分10
17秒前
懵懂的土豆完成签到,获得积分10
17秒前
你还是要加油完成签到,获得积分10
17秒前
lwj6855发布了新的文献求助10
18秒前
George完成签到,获得积分10
20秒前
CipherSage应助xu采纳,获得10
20秒前
juno完成签到,获得积分10
20秒前
夏樱完成签到 ,获得积分10
20秒前
搜集达人应助火花采纳,获得10
20秒前
风收奇绩完成签到,获得积分10
20秒前
hello_25baby完成签到,获得积分10
21秒前
Hyde完成签到,获得积分10
22秒前
23秒前
23秒前
Xiaohu完成签到,获得积分10
23秒前
罗尔与柯西完成签到,获得积分10
23秒前
高分求助中
Evolution 10000
ISSN 2159-8274 EISSN 2159-8290 1000
Becoming: An Introduction to Jung's Concept of Individuation 600
Ore genesis in the Zambian Copperbelt with particular reference to the northern sector of the Chambishi basin 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3162727
求助须知:如何正确求助?哪些是违规求助? 2813601
关于积分的说明 7901404
捐赠科研通 2473189
什么是DOI,文献DOI怎么找? 1316684
科研通“疑难数据库(出版商)”最低求助积分说明 631482
版权声明 602175