Sepsis is the leading cause of death in burn patients. Interventions are challenging owing to a lack of specific guidelines. All burn types involve a risk for complications. Interventions should include care of the burn, medication administration, continuous monitoring for infection development, infection prevention measures, and (if necessary) treatment of sepsis. Sepsis in burn patients is different from the unburned population. Efforts are needed to develop more accurate diagnostic strategies and guidelines to trigger rapid treatment via specific sepsis bundles.