USP10 regulates Musashi‐2 stability via deubiquitination and promotes tumour proliferation in colon cancer

Recent studies have demonstrated that ubiquitin‐specific protease 10 ( USP 10) plays a catalytic role in tumour suppression mainly by deubiquitinating its target proteins to enhance their stabilities. However, we found that USP 10 could interact with and regulate the expression of oncogenic factor Musashi‐2 ( MSI 2). We investigated whether USP 10 positively regulates the expression of MSI 2 by deubiquitination and confirmed the type of polyubiquitin chain that is linked to MSI 2. We also explored the role of USP 10 in regulating the proliferation of colon cancer through different experiments. This study provides a completely new perspective in understanding the role of USP 10 in deubiquitination. In the future, USP 10 may serve as a target for colon cancer treatment.