癌症
癌症治疗
材料科学
纳米技术
癌症治疗
癌症研究
环磷酰胺
癌细胞
医学
内科学
化疗
作者
Shenglin Luo,Xu Tan,Qingrong Qi,Qinyuan Guo,Xinze Ran,Lilong Zhang,Erlong Zhang,Yufeng Liang,Lingling Weng,Hu Zheng,Tianmin Cheng,Yongping Su,Chunmeng Shi
出处
期刊:Biomaterials
[Elsevier BV]
日期:2012-12-21
卷期号:34 (9): 2244-2251
被引量:85
标识
DOI:10.1016/j.biomaterials.2012.11.057
摘要
Personalized oncology significantly relies on the development of cancer theranostic agents to integrate cancer therapeutics and diagnostics. Current most common strategy for development of such multifunctional agents requires multistep chemical conjugation with cancer targeted ligands, contrast agents and therapeutic agents. Here we report the chemical synthesis and biological characterization of a new heptamethine dye, termed as IR-808DB, natively with multifunctional characteristics of cancer targeting, near-infrared fluorescence imaging, and efficient anticancer activity. The tumor inhibition effect of IR-808DB is higher than that of cyclophosphamide (CTX) toward a broad spectrum of tumor xenograft models. These findings provide IR-808DB a promising prospect as a new cancer theranostic agent that would enable integration of cancer targeted therapeutics and diagnostics without requirement of multi-component chemical conjugation.
科研通智能强力驱动
Strongly Powered by AbleSci AI