Nardosinane-type sesquiterpenoids of Nardostachys chinensis Batal

Four new nardosinane-type sesquiterpenoids nardosinanones F–I (1–2, 4–5), along with eight known sesquiterpenoids (3, 6–12) were isolated from the underground parts of Nardostachys chinensis Batal. Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 1 and 2 were new nardosinane sesquiterpenoids processing a rare 4,11-epoxy group in nature. In addition, compounds 1, 5–7, 11 and 12 showed protective effects on neonatal rat cardiomyocyte injury induced by hydrogen peroxide.