Cytokines in Patients with Polytrauma

Patients with multiple injuries have alterations in hemodynamic, metabolic, and immune responses that largely are orchestrated by endogenous mediators referred to as cytokines. At the molecular level cytokines act as architects constructing a blueprint which ultimately will become the clinical "Big Picture"; however, the exact role and extent each cytokine has is still in question. In addition, the surface of research opportunities has nearly been scratched regarding the best way to control or manipulate the cytokine response in efforts to improve care for the trauma patient. Systemically organisms respond to injury regardless of the cause (hemorrhage, ischemia, reperfusion, fracture, and tissue damage) by attempting to restore homeostasis, which involves a coordination of the immune, cardiovascular, endocrine, and nervous systems. This systemic response can result in severe immunologic compromise that threatens the survival of patients with trauma. It seems that it is this balance or imbalance of cytokines, along with other associative factors, that controls the eventual clinical pathway a patient will take. Blood mediator concentrations often parallel the inflammatory process, and high levels of cytokines can be followed by severe organ dysfunction. Certain cytokine levels, such as the interleukins, can be used in predictive ways to correlate organ failure in multiply injured patients. Although much more research must be done, there is great promise in the study of cytokines through basic science research and clinical trials.