Partial protection of carbohydrate derivatives. part 18. simple, preparative procedure for 5'--acylribonucleosides; highly regioselective -deacylation at 2' and 3' positions of fully acylated purine and pyrimidine ribonucleoside through sodium methoxide-thf system

Abstract A treatment of fully acylated purine and pyrimidine ribonucleosides with a small excess amount of sodium methoxide in THF at room temperature gave the corresponding 5'-acylates in excellent yields; N -acyl groups on the nucleic acid base moieties of adenosine and cytidine in addition to guanosine derivatives satisfactorily survived under the conditions used.