免疫系统
谱系(遗传)
免疫学
T辅助细胞
T细胞
细胞分化
细胞因子
生物
细胞生物学
遗传学
基因
作者
John J. O’Shea,William E. Paul
出处
期刊:Science
[American Association for the Advancement of Science]
日期:2010-02-25
卷期号:327 (5969): 1098-1102
被引量:1277
标识
DOI:10.1126/science.1178334
摘要
Critical Mediators Helper T cells are the immune system's ringmasters, having a multiplicity of functions that mediate the body's immune responses to infections. Depending on the type of infection, CD4 + helper T cells respond by secreting specific patterns of cytokines, which provide important cues to other subsets of immune cells. CD4 + T cells with distinct cytokine profiles have been viewed classically as separate lineages; however, there is mounting evidence that these cells may not be terminally differentiated but are in fact quite plastic. O'Shea and Paul (p. 1098 ) review the current understanding of CD4 + T cell subset differentiation and the underlying mechanisms that drive cell-lineage commitment.
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