Chemical constituents of Cyrtomium fortumei (J.) Smith

Five known compounds, 6'-methylglucuronide-5-hydroxy-chromone (1), ethyl α-d-glactopyranoside (2), neoechinulin A (3), 9,12,13-trihydroxyoctadeca-10(E),15(Z)-dienoic acid (4) and phellopterin (5), were isolated from water extract of Cyrtomium fortumei (J.) Smith. Compounds 1-5 were isolated from this genus for the first time, and all the compounds were evaluated in vitro against a panel of human cancer cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Among them, compounds 3 and 4 exhibited significant cytotoxic activities, with IC50 values of 15.2 and 18.3 μg/mL on MGC-803 cells, respectively.