祖细胞
趋化因子
CXCR4型
细胞生物学
再生(生物学)
生物
内皮干细胞
干细胞
祖细胞
炎症
血管生成
免疫学
癌症研究
体外
遗传学
作者
Paola Salvatore,Caterina Pagliarulo,Roberta Colicchio,Claudio Napoli
标识
DOI:10.2174/092986710791959792
摘要
The endothelial progenitor cells (EPCs) are angiogenic cells having properties similar to those of embryonal angioblasts. The number and function of EPCs are affected by a variety of conditions, including cytokines and chemokines, which are pivotal inflammatory signaling molecules. The purpose of this paper is to review current knowledge about the role of these progenitor in different vascular diseases, emphasizing the important biological role played from the CXCR4-CXCL12 axis in the cellular trafficking. Indeed, as described in detail in this review, the CXCR4/CXCL12 interaction produces pleiotropic effects in stem cells and plays a pivotal role in several processes related to development, tissue regeneration and development/progression of malignancies.
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