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Guinea pigs reared in a monochromatic environment exhibit changes in cone density and opsin expression

视蛋白 单色 生物 视网膜 视紫红质 豚鼠 视网膜 颜料 分子生物学 化学 生物化学 植物 内分泌学 神经科学 有机化学
作者
Min Hu,Zhulin Hu,Leigang Xue,Zhimin Yang,Ziming Zheng,Dan He,Xiaofan Zhang
出处
期刊:Experimental Eye Research [Elsevier BV]
卷期号:93 (6): 804-809 被引量:12
标识
DOI:10.1016/j.exer.2011.09.013
摘要

This study aimed to determine if a monochromatic environment will affect the development of cones in a guinea pig model. Thirty 3-day-old guinea pigs were randomized into three groups and exposed to green, violet, and white light (control) for 8 weeks. The animals were sacrificed and the density of middle-wavelength cones (M cones) and short-wavelength sensitive (S cones) and expression of M-opsin and S-opsin were determined. The density of M cones was increased in the green light group as compared to the control group, and decreased in the violet light group as compared to the control group (both, p < 0.05). There was no significant difference in the density of the S cones among the groups (all, p > 0.05). The density of coexpressing cones in the middle retina was significantly increased in the green light group in comparison to the violet light group (p < 0.01). In addition, there was a significant increase in the level of M-opsin as determined by Western blotting and M-opsin mRNA expression as determined by PCR analysis in the green light group as compared to the control group and a significant decrease in violet light group as compared to the control group (all, p < 0.05). No significant difference in S-opsin level or S-opsin mRNA expression was noted among the groups. We concluded that monochromatic lighting affected the density of cones and expression of opsins in a guinea pig model, and this indicates that the retinal color visual system of the guinea pig possess developmental plasticity.
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