子痫前期
滋养层
胎盘形成
细胞凋亡
医学
胎盘
怀孕
Fas配体
趋化因子
男科
免疫学
内科学
内分泌学
程序性细胞死亡
胎儿
炎症
生物
遗传学
出处
期刊:Journal of Perinatal Medicine
[De Gruyter]
日期:2005-01-01
卷期号:33 (6)
被引量:50
摘要
It has become clear in recent years that apoptosis is a normal process in trophoblast turnover during pregnancy. Increased trophoblast apoptosis has been observed in the placenta of women with preeclampsia, serum from women with preeclampsia has been found to induce increased trophoblast sensitivity to Fas-mediated apoptosis, and serum from women with preeclampsia has elevated levels of various chemokines, growth factors and cytokines that are involved in the regulation of apoptosis. This review highlights the importance of apoptosis in normal placental development and explores the mechanisms whereby Fas-mediated apoptosis may play a role in conditions related to abnormal placentation, such as preeclampsia.
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