溶血磷脂酸
信号转导
上瘾
脂质信号
细胞生物学
化学
药理学
医学
神经科学
生物
生物化学
受体
作者
Laura Orío,Francisco Javier Pavón,Eduardo Blanco,Antonia Serrano,Pedro Araos,María Pilar San Nicolás Pedraz,Patricia Rivera,Montserrat Calado,Juan Suárez,Fernando Rodrı́guez de Fonseca
标识
DOI:10.2174/138161281940131209143421
摘要
This review analyzes the roles of lipid transmitters, especially those derived from the cleavage of membrane phospholipids, in cocaine-associated behaviors. These lipid signals are important modulators of information processing in the brain, affecting transmitter release, neural plasticity, synaptogenesis, neurogenesis, and cellular energetics. This broad range of actions makes them suitable targets for pharmaceutical development of cocaine addiction therapies because they participate in the main cellular processes underlying the neuroadaptations associated with chronic use of this psychostimulant. The main lipid transmitters reviewed here include a) acylethanolamides and acylglycerols acting on cannabinoid receptors, such as anandamide and 2-arachidonoylglycerol; b) acylethanolamides that do not act on cannabinoid receptors, such as oleoylethanolamide; c) eicosanoids derived from arachidonic acid, including prostaglandins; and d) lysophosphatidic acid, focusing on the role of its LPA-1 receptor. Direct experimental evidence for the significance of these lipids in cocaine-related behaviors is presented and discussed. Additionally, the roles for both their biosynthesis and degradation pathways, as well as the participation of their receptors, are examined. Overall, lipid transmitter signaling can offer new targets for the development of therapies for cocaine addiction. Keywords: Oleoylethanolamide, PPARα, knockout, cocaine, motor sensitization, reinforcement.
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