吞噬作用
抗原呈递
细胞生物学
生物
巨噬细胞
树突状细胞
抗原
主要组织相容性复合体
获得性免疫系统
抗原提呈细胞
免疫系统
免疫学
先天免疫系统
交叉展示
细胞毒性
吞噬体
T细胞
体外
生物化学
作者
Ariel Savina,Sébastian Amigorena
标识
DOI:10.1111/j.1600-065x.2007.00552.x
摘要
Summary: Like macrophages and neutrophils, dendritic cells (DCs) are considered professional phagocytes. Even if the three cell types phagocytose parasites, bacteria, cell debris, or even intact cells very efficiently, the functional outcomes of the phagocytic event are quite different. Macrophages and neutrophils scavenge and destroy phagocytosed particles, a critical step in innate immunity. DCs, in contrast, have developed means to ‘preserve’ useful information from the ingested particles that serve to initiate adaptive immune responses. Thus, both phagosomal degradation and acidification are much lower in DCs than in macrophages or neutrophils. Reduced degradation results in the conservation of antigenic peptides and in their increased presentation on major histocompatibility complex class I and II molecules. In this article, we review the mechanisms that control this delicate equilibrium between phagosomal degradation/cytotoxicity and antigen presentation in the different families of phagocytes.
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