生物
溶解循环
病毒学
免疫系统
病毒
马立克氏病
CTL公司*
细胞毒性T细胞
表位
病毒复制
免疫学
病毒潜伏期
抗原
CD8型
生物化学
体外
作者
Karel A. Schat,Zheng Xing
标识
DOI:10.1016/s0145-305x(99)00073-7
摘要
Marek’s disease (MD) virus (MDV) has provided an important model to study immune responses against a lymphoma-inducing herpesvirus in its natural host. Infection in chickens starts with a lytic infection in B cells, followed by a latent infection in T cells and, in susceptible birds, T cell lymphomas develop. Non-specific and specific immune responses are important for the control of virus infection and subsequent tumor development. Interferon-γ and nitric oxide are important for the control of virus replication during the lytic phase of infection and are also important to prevent reactivation of MDV replication in latently infected and transformed cells. Cytotoxic T cells (CTLs) are the most important of the specific immune responses in MDV. In addition to antigen-specific CTL against MDV proteins pp38, glycoprotein B (gB), Meq, and ICP4, ICP27-specific CTL can also be detected as early as 6 to 7 days post infection. The epitope for gB recognized by CTLs from P2a (MHC: B19B19) chickens has been localized to the Eco47III-BamHI (nucleotides 1515–1800) fragment. A proposed model for the interactions of cytokines and immune responses as part of the pathogenesis of MD is discussed.
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