肠易激综合征
医学
发病机制
肠动力
小肠细菌生长过度
益生菌
疾病
肠道菌群
短肠综合征
细菌
肠粘膜
胃肠病学
微生物学
免疫学
内科学
运动性
生物
肠外营养
遗传学
作者
Giovanni Barbara,Vincenzo Stanghellini,Giovanni Brandi,Cesare Cremon,Giovanni Di Nardo,Roberto De Giorgio,Roberto Corinaldesi
标识
DOI:10.1111/j.1572-0241.2005.00230.x
摘要
Commensal bacteria inhabiting the human intestine (i.e., intestinal microflora) participate in the development and maintenance of gut sensory and motor functions, including the promotion of intestinal propulsive activity. On the other hand, intestinal motility represents one of the major control systems of gut microflora, through the sweeping of excessive bacteria from the lumen. There is emerging evidence indicating that changes in this bidirectional interplay contribute to the pathogenesis of gut diseases, such as small intestinal bacterial overgrowth and intestinal pseudo-obstruction. Recent interest has also been directed to the potential role of intestinal microflora in the pathogenesis of the irritable bowel syndrome. Although the status of intestinal microflora in the irritable bowel syndrome remains unsettled, small intestinal bacterial overgrowth (as detected with breath testing) and increased fermentation of foods with gas production, provide indirect evidence that microflora may contribute to symptom generation in irritable bowel syndrome. The potential benefit of antibiotic and probiotic therapy is currently under investigation and opens new perspectives in irritable bowel syndrome treatment.
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