Apolipoprotein E allele in centenarians

Sobel et al., 1 reporting the prevalence of apolipoprotein E (apoE) genotypes among Finnish centenarians, noted that the presence of the e4 allele does not necessarily lead to Alzheimer's disease (AD) in this population and suggested that the relationship between the apoE e4 allele and AD may be age-dependent. Recently, we also carried out an almost complete survey of centenarians living in Yamanashi prefecture, a district of Japan with a population of 0.87 million, and determined the prevalence of apoE …