Phase II randomized, placebo-controlled trial of phytotherapeutic product Catuama for breast cancer women undergoing adjuvant radiation therapy.

医学 安慰剂 乳腺癌 医院焦虑抑郁量表 内科学 随机对照试验 生活质量(医疗保健) 癌症 不利影响 萧条(经济学) 外科 焦虑 精神科 病理 护理部 经济 替代医学 宏观经济学
作者
Felipe Melo Cruz,Daniel de Iracema Gomes Cubero,Patrícia Xavier Santi,Luciana Garcia Landeiro,Andressa Sayuri Tamashiro,Larisse Soares Ribeiro,Auro del Giglio
出处
期刊:Journal of Clinical Oncology [American Society of Clinical Oncology]
卷期号:31 (15_suppl): e20524-e20524
标识
DOI:10.1200/jco.2013.31.15_suppl.e20524
摘要

e20524 Background: Fatigue and Depression are common in patients undergoing Breast Cancer (BC) treatment. Catuama is a registered phytotherapic that contains 4 brazilian herbs per capsule: Trichilia catigua (87.5mg), Ptychopetalum olacoides (87.5mg), Paullinia cupana (125 mg) and Zingiber officinale (10mg). Objectives: Since one of its constituents is Guarana (Paulinia cupana) which we already reported to have anti-fatigue effects, we decided to test Catuama potential anti-fatigue effects in BC women undergoing adjuvant 4 weeks of Radiation Therapy (RxT). Methods: This is a double blinded, randomized, placebo-controlled, Phase II cross-over trial. Patients with histologically proven BC with the indication of adjuvant RxT, non-pregnant nor breastfeeding, older than 18 years of age, with ECOG PS 0 or 1, without a history of cardiac, renal, hepatic or psychiatric decompensation, received Catuama 1 capsule twice daily versus a matching placebo for the first 2 weeks of RxT treatment, followed by a week of wash out, followed by an additional two weeks of treatment with crossover of experimental arms. Patients were evaluated on days 1, 15 and 36 with the Brief Fatigue Inventory (BFI), Hospital Anxiety and Depression Scale (HADS), Quality of Life FACIT-F, FACIT-ES questionnaires, and Chalder Fatigue scale. Results: We enrolled 90 patients with a median age of 53 years (26 – 80). We saw no statistically significant differences of FACIT ES, FACIT F, HADS, Chalder or BFI scores treated with Catuama or Placebo when we considered all included patients. When we selected only patients with a BFI score above 30, Catuama significantly decreased BFI scores as compared to baseline (p<0.0001). We observed one instance of grade 3 hypermagnesemia in the Catuama arm and one patient had hyperglicemia grade 3 both in the Catuama and in the placebo arm. No grade 4 toxicities were seen. Conclusions: Catuama may help selected patients who already start RxT with evidence of fatigue.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
1秒前
Twikky完成签到,获得积分10
2秒前
如意歌曲发布了新的文献求助50
3秒前
11122发布了新的文献求助10
3秒前
xusansui321发布了新的文献求助10
6秒前
www发布了新的文献求助10
6秒前
SciGPT应助现代的木子采纳,获得10
6秒前
爆裂奶綠完成签到,获得积分10
7秒前
神奇的光子完成签到,获得积分10
8秒前
9秒前
会飞的鱼完成签到,获得积分10
9秒前
10秒前
万能图书馆应助clevenx采纳,获得10
10秒前
feitian201861完成签到,获得积分10
11秒前
刘秀完成签到 ,获得积分10
11秒前
科目三应助xusansui321采纳,获得10
13秒前
大王869完成签到 ,获得积分10
13秒前
14秒前
H喜欢老霉完成签到 ,获得积分10
14秒前
今麦郎发布了新的文献求助10
15秒前
炙热的雅霜完成签到,获得积分10
16秒前
机灵的冰夏完成签到,获得积分10
16秒前
18秒前
呼呼哈哈完成签到,获得积分10
18秒前
李健应助拥抱草地的胖子采纳,获得20
18秒前
20秒前
Lu完成签到,获得积分10
22秒前
clevenx发布了新的文献求助10
23秒前
李健应助深情的芷巧采纳,获得30
24秒前
孙旭发布了新的文献求助10
24秒前
余存发布了新的文献求助20
24秒前
玄武岩发布了新的文献求助10
25秒前
NATURECATCHER完成签到,获得积分10
25秒前
所所应助栗子采纳,获得10
26秒前
NULI完成签到 ,获得积分10
27秒前
喜汁郎完成签到,获得积分10
31秒前
詹密完成签到,获得积分10
31秒前
xiaoou完成签到 ,获得积分10
32秒前
称心茹嫣完成签到 ,获得积分10
34秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Evolution 3rd edition 1500
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3187734
求助须知:如何正确求助?哪些是违规求助? 2837488
关于积分的说明 8015060
捐赠科研通 2500112
什么是DOI,文献DOI怎么找? 1334764
科研通“疑难数据库(出版商)”最低求助积分说明 637271
邀请新用户注册赠送积分活动 605251