清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Phase II randomized, placebo-controlled trial of phytotherapeutic product Catuama for breast cancer women undergoing adjuvant radiation therapy.

医学 安慰剂 乳腺癌 医院焦虑抑郁量表 内科学 随机对照试验 生活质量(医疗保健) 癌症 不利影响 萧条(经济学) 外科 焦虑 精神科 病理 护理部 经济 替代医学 宏观经济学
作者
Felipe Melo Cruz,Daniel de Iracema Gomes Cubero,Patrícia Xavier Santi,Luciana Garcia Landeiro,Andressa Sayuri Tamashiro,Larisse Soares Ribeiro,Auro del Giglio
出处
期刊:Journal of Clinical Oncology [American Society of Clinical Oncology]
卷期号:31 (15_suppl): e20524-e20524
标识
DOI:10.1200/jco.2013.31.15_suppl.e20524
摘要

e20524 Background: Fatigue and Depression are common in patients undergoing Breast Cancer (BC) treatment. Catuama is a registered phytotherapic that contains 4 brazilian herbs per capsule: Trichilia catigua (87.5mg), Ptychopetalum olacoides (87.5mg), Paullinia cupana (125 mg) and Zingiber officinale (10mg). Objectives: Since one of its constituents is Guarana (Paulinia cupana) which we already reported to have anti-fatigue effects, we decided to test Catuama potential anti-fatigue effects in BC women undergoing adjuvant 4 weeks of Radiation Therapy (RxT). Methods: This is a double blinded, randomized, placebo-controlled, Phase II cross-over trial. Patients with histologically proven BC with the indication of adjuvant RxT, non-pregnant nor breastfeeding, older than 18 years of age, with ECOG PS 0 or 1, without a history of cardiac, renal, hepatic or psychiatric decompensation, received Catuama 1 capsule twice daily versus a matching placebo for the first 2 weeks of RxT treatment, followed by a week of wash out, followed by an additional two weeks of treatment with crossover of experimental arms. Patients were evaluated on days 1, 15 and 36 with the Brief Fatigue Inventory (BFI), Hospital Anxiety and Depression Scale (HADS), Quality of Life FACIT-F, FACIT-ES questionnaires, and Chalder Fatigue scale. Results: We enrolled 90 patients with a median age of 53 years (26 – 80). We saw no statistically significant differences of FACIT ES, FACIT F, HADS, Chalder or BFI scores treated with Catuama or Placebo when we considered all included patients. When we selected only patients with a BFI score above 30, Catuama significantly decreased BFI scores as compared to baseline (p<0.0001). We observed one instance of grade 3 hypermagnesemia in the Catuama arm and one patient had hyperglicemia grade 3 both in the Catuama and in the placebo arm. No grade 4 toxicities were seen. Conclusions: Catuama may help selected patients who already start RxT with evidence of fatigue.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
22秒前
juan完成签到 ,获得积分10
24秒前
27秒前
lyp完成签到 ,获得积分10
27秒前
wangye完成签到 ,获得积分10
1分钟前
斯文的妙海完成签到 ,获得积分10
2分钟前
2分钟前
3分钟前
Wu发布了新的文献求助10
3分钟前
隐形蜡烛完成签到,获得积分20
5分钟前
隐形蜡烛发布了新的文献求助10
5分钟前
子月之路完成签到,获得积分10
5分钟前
energyharvester完成签到 ,获得积分10
6分钟前
无花果应助BruceZh采纳,获得10
7分钟前
7分钟前
jyy应助科研通管家采纳,获得10
7分钟前
BruceZh发布了新的文献求助10
7分钟前
Alan完成签到 ,获得积分10
7分钟前
肆肆完成签到,获得积分10
8分钟前
Sandy发布了新的文献求助10
8分钟前
jyy应助科研通管家采纳,获得10
9分钟前
jyy应助科研通管家采纳,获得10
11分钟前
所得皆所愿完成签到 ,获得积分10
12分钟前
zsmj23完成签到 ,获得积分0
12分钟前
higgs完成签到,获得积分10
13分钟前
糖伯虎完成签到 ,获得积分10
14分钟前
14分钟前
hui完成签到,获得积分10
14分钟前
hui关闭了hui文献求助
14分钟前
15分钟前
hui发布了新的文献求助10
15分钟前
小白完成签到 ,获得积分10
15分钟前
16分钟前
觅雪格发布了新的文献求助10
16分钟前
华仔应助鱼日采纳,获得150
17分钟前
17分钟前
17分钟前
Charlie完成签到 ,获得积分10
18分钟前
18分钟前
觅雪格完成签到 ,获得积分10
18分钟前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Aspects of Babylonian celestial divination: the lunar eclipse tablets of Enūma Anu Enlil 500
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
Dictionary of socialism 350
Mixed-anion Compounds 300
Geochemistry, 2nd Edition 地球化学经典教科书第二版 300
Idoxuridine 260
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3196776
求助须知:如何正确求助?哪些是违规求助? 2845469
关于积分的说明 8054209
捐赠科研通 2510065
什么是DOI,文献DOI怎么找? 1342246
科研通“疑难数据库(出版商)”最低求助积分说明 639349
邀请新用户注册赠送积分活动 608662