已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Phase II randomized, placebo-controlled trial of phytotherapeutic product Catuama for breast cancer women undergoing adjuvant radiation therapy.

医学 安慰剂 乳腺癌 医院焦虑抑郁量表 内科学 随机对照试验 生活质量(医疗保健) 癌症 不利影响 萧条(经济学) 外科 焦虑 精神科 病理 护理部 经济 替代医学 宏观经济学
作者
Felipe Melo Cruz,Daniel de Iracema Gomes Cubero,Patrícia Xavier Santi,Luciana Garcia Landeiro,Andressa Sayuri Tamashiro,Larisse Soares Ribeiro,Auro del Giglio
出处
期刊:Journal of Clinical Oncology [American Society of Clinical Oncology]
卷期号:31 (15_suppl): e20524-e20524
标识
DOI:10.1200/jco.2013.31.15_suppl.e20524
摘要

e20524 Background: Fatigue and Depression are common in patients undergoing Breast Cancer (BC) treatment. Catuama is a registered phytotherapic that contains 4 brazilian herbs per capsule: Trichilia catigua (87.5mg), Ptychopetalum olacoides (87.5mg), Paullinia cupana (125 mg) and Zingiber officinale (10mg). Objectives: Since one of its constituents is Guarana (Paulinia cupana) which we already reported to have anti-fatigue effects, we decided to test Catuama potential anti-fatigue effects in BC women undergoing adjuvant 4 weeks of Radiation Therapy (RxT). Methods: This is a double blinded, randomized, placebo-controlled, Phase II cross-over trial. Patients with histologically proven BC with the indication of adjuvant RxT, non-pregnant nor breastfeeding, older than 18 years of age, with ECOG PS 0 or 1, without a history of cardiac, renal, hepatic or psychiatric decompensation, received Catuama 1 capsule twice daily versus a matching placebo for the first 2 weeks of RxT treatment, followed by a week of wash out, followed by an additional two weeks of treatment with crossover of experimental arms. Patients were evaluated on days 1, 15 and 36 with the Brief Fatigue Inventory (BFI), Hospital Anxiety and Depression Scale (HADS), Quality of Life FACIT-F, FACIT-ES questionnaires, and Chalder Fatigue scale. Results: We enrolled 90 patients with a median age of 53 years (26 – 80). We saw no statistically significant differences of FACIT ES, FACIT F, HADS, Chalder or BFI scores treated with Catuama or Placebo when we considered all included patients. When we selected only patients with a BFI score above 30, Catuama significantly decreased BFI scores as compared to baseline (p<0.0001). We observed one instance of grade 3 hypermagnesemia in the Catuama arm and one patient had hyperglicemia grade 3 both in the Catuama and in the placebo arm. No grade 4 toxicities were seen. Conclusions: Catuama may help selected patients who already start RxT with evidence of fatigue.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Amber完成签到 ,获得积分10
1秒前
肘子杨发布了新的文献求助10
3秒前
zhan20200503发布了新的文献求助10
13秒前
16秒前
舒心老五发布了新的文献求助10
19秒前
科研通AI2S应助Yimi采纳,获得10
20秒前
小石榴的爸爸完成签到 ,获得积分10
25秒前
小石榴爸爸完成签到 ,获得积分10
30秒前
科研通AI2S应助Yimi采纳,获得10
32秒前
33秒前
烊驼完成签到,获得积分10
35秒前
Syj2468完成签到 ,获得积分10
36秒前
干净博涛完成签到 ,获得积分10
37秒前
HEIKU应助科研通管家采纳,获得10
38秒前
赘婿应助科研通管家采纳,获得10
38秒前
Owen应助科研通管家采纳,获得10
38秒前
慕青应助科研通管家采纳,获得10
38秒前
HEIKU应助科研通管家采纳,获得10
38秒前
深情安青应助科研通管家采纳,获得10
38秒前
39秒前
可久斯基完成签到 ,获得积分10
39秒前
可爱的函函应助sugarballer采纳,获得30
43秒前
wyz完成签到,获得积分10
45秒前
科研通AI2S应助芒果豆豆采纳,获得10
46秒前
耍酷鼠标完成签到 ,获得积分0
46秒前
胡高照发布了新的文献求助10
48秒前
Survivor完成签到,获得积分10
55秒前
Geist完成签到 ,获得积分10
56秒前
科研通AI2S应助俭朴的猫咪采纳,获得10
58秒前
胡高照完成签到,获得积分20
58秒前
青岩完成签到,获得积分10
1分钟前
天天好心覃完成签到 ,获得积分10
1分钟前
imomoe完成签到,获得积分10
1分钟前
江小白完成签到,获得积分0
1分钟前
早早早完成签到,获得积分10
1分钟前
Zz完成签到,获得积分10
1分钟前
1分钟前
罗美美完成签到,获得积分10
1分钟前
专注的帆布鞋完成签到 ,获得积分10
1分钟前
1分钟前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
2-Acetyl-1-pyrroline: an important aroma component of cooked rice 500
A real-time energy management strategy based on fuzzy control and ECMS for PHEVs 400
Handbook on People's China (1957) 400
2024 Medicinal Chemistry Reviews 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3189894
求助须知:如何正确求助?哪些是违规求助? 2839133
关于积分的说明 8023069
捐赠科研通 2502078
什么是DOI,文献DOI怎么找? 1336196
科研通“疑难数据库(出版商)”最低求助积分说明 637804
邀请新用户注册赠送积分活动 605852